A pilot study on ex vivo expanded autologous adipose‐derived stem cells of improving fat retention in localized scleroderma patients

In patients with localized scleroderma (LoS), facial deformity induced by subcutaneous atrophy greatly reduces life quality. Autologous fat grafting (AFG) is used for volume restoration but with low‐fat retention due to various reasons. Adipose‐derived stem cells (ADSCs) have shown potential effects...

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Bibliographic Details
Published in:Stem cells translational medicine 2021-08, Vol.10 (8), p.1148-1156
Main Authors: Wang, Chenyu, Long, Xiao, Si, Loubin, Chen, Bo, Zhang, Yiwei, Sun, Tianyu, Zhang, Xiuqin, Zhao, Robert Chunhua, Wang, Xiaojun
Format: Article
Language:English
Subjects:
Adipocytes
Adipose Stem Cells/VSF
adipose‐derived stem cells
Adverse events
Atrophy
Autografts
Body mass index
Clinical outcomes
Clinical trials
Dermatology
fat grafting
Flow cytometry
Human Clinical
Liposuction
localized scleroderma
Magnetic resonance imaging
Medical research
Medicine, Experimental
Patients
Quality of life
Reconstructive surgery
Retention
Scleroderma
Scleroderma (Disease)
Stem cells
stromal vascular fraction
Systemic scleroderma
Transplants & implants
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Summary:In patients with localized scleroderma (LoS), facial deformity induced by subcutaneous atrophy greatly reduces life quality. Autologous fat grafting (AFG) is used for volume restoration but with low‐fat retention due to various reasons. Adipose‐derived stem cells (ADSCs) have shown potential effects in improving fat retention. We aimed to compare the feasibility and efficacy of improving fat retention in LoS patients among the ADSCs‐assisted, the stromal vascular fraction (SVF)‐assisted and conventional AFG methods. A pilot study with a 6‐month follow‐up among 18 LoS patients was conducted. Participants were randomly assigned into three AFG groups: conventional group, SVF‐assisted group, and ADSCs‐assisted group. The SVF‐assisted group received SVF‐assisted AFG at the SVF:fat ratio of 1:1. The ADSCs‐assisted group received the mixture of ADSCs‐enriched fat graft supplemented with 5 × 105 ADSCs/mL fat. Volume retention was measured by magnetic resonance imaging, and clinical photographs were taken for outcome evaluation. At sixth‐month follow‐up, the fat retention of ADSCs‐assisted group was 49.83 ± 3.61%, significantly higher than 31.75 ± 1.73% of SVF‐assisted group (P = .0004), and 21.86 ± 1.68% of the conventional group (P 
ISSN:2157-6564
2157-6580
2157-6580
DOI:10.1002/sctm.20-0419