Effect of ABCA1 promoter methylation on premature coronary artery disease and its relationship with inflammation

ATP-binding cassette transporter A1 (ABCA1) plays a major role in high-density lipoprotein (HDL) metabolism and reverse cholesterol transport (RCT) and exerts anti-inflammatory effects. Increased ABCA1 promoter methylation level may result in the progression of coronary artery disease. Thus, the pre...

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Bibliographic Details
Published in:BMC cardiovascular disorders 2021-02, Vol.21 (1), p.78-78, Article 78
Main Authors: An, Fang, Liu, Chao, Wang, Xiujuan, Li, Tan, Fu, Hao, Bao, Buhe, Cong, Hongliang, Zhao, Jihong
Format: Article
Language:English
Subjects:
ABCA1 protein
Age
ATP-binding cassette transporter
ATP-binding protein
Blood cholesterol
C-reactive protein
Cardiology
Cardiovascular disease
Carrier proteins
Cholesterol
Coronary artery
Coronary artery disease
Coronary heart disease
Coronary vessels
Deoxyribonucleic acid
Development and progression
Diabetes
Disease prevention
DNA
DNA methylation
Enzymes
Gene expression
HDL cholesterol
Health aspects
Heart attacks
Heart diseases
High density lipoprotein
Hypertension
IL-1β
Inflammation
Leukocytes (neutrophilic)
Lipid metabolism
Lipids
Medical imaging
Metabolism
Methylation
Multiple regression analysis
Neutrophil extracellular traps
Physiological aspects
Risk factors
Serum levels
Software
Statistical analysis
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Summary:ATP-binding cassette transporter A1 (ABCA1) plays a major role in high-density lipoprotein (HDL) metabolism and reverse cholesterol transport (RCT) and exerts anti-inflammatory effects. Increased ABCA1 promoter methylation level may result in the progression of coronary artery disease. Thus, the present study investigated the association between promoter methylation status of ABCA1 and inflammation in the development of premature coronary artery disease (pCAD). PCAD patients and healthy individuals (n = 90 each) were recruited from the Characteristic Medical Center of the Chinese People's Armed Police Force from June to December 2019. Using pyrosequencing, the levels of ABCA1 promoter methylation in their blood samples were evaluated. Serum concentrations of lipids, interleukin 1β (IL-1β), C-reactive protein (CRP), and circulating free DNA/Neutrophil extracellular traps (cfDNA/NETs) were also routinely measured and compared between the two groups. P values 
ISSN:1471-2261
1471-2261
DOI:10.1186/s12872-021-01894-x