Antibacterial Activity of Bisanthraquinone (+)-1,1’-Bislunatin

Endophytic fungi has been known as a source of biologically active compunds with a broad sprectrum of activities. One of the endophytic fungi isolated from young stem of gambier plant (Uncaria gambier Roxb.:Rubiaceae), Diaporthe sp. GNBP-10, produced (+)-1,1’-bislunatin when cultivated on potato dex...

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Bibliographic Details
Published in:Microbiology Indonesia 2014-05, Vol.7 (4), p.159-166
Main Authors: PRAPTIWI, PRAPTIWI, JAMAL, YULIASRI, FATHONI, AHMAD, NURKANTO, ARIF, AGUSTA, ANDRIA
Format: Article
Language:English
Subjects:
1
1’-bislunatin
antibacterial
Diaporthe sp
effect on bacterial cells
endophytic fungus
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Summary:Endophytic fungi has been known as a source of biologically active compunds with a broad sprectrum of activities. One of the endophytic fungi isolated from young stem of gambier plant (Uncaria gambier Roxb.:Rubiaceae), Diaporthe sp. GNBP-10, produced (+)-1,1’-bislunatin when cultivated on potato dextrose agar (PDA). (+)-1,1’-Bislunatin showed moderate antibacterial activity against 7 bacteria (Bacillus subtilis, Staphylococcus aureus, Escherichia coli, Micrococcus luteus, Shigella flexneri, Proteus vulgaris, and P. mirabilis) with MIC value in the range of  32-64 µg mL-1. The wall disruption and morphological changes in the cells affected by exposure of (+)-1,1’-bislunatin are also discussed in this article.
ISSN:1978-3477
2087-8575
DOI:10.5454/mi.7.4.4