Clinical and pathological implications of miRNA in bladder cancer

MicroRNAs (miRNAs) are small, noncoding RNA species with a length of 20-22 nucleotides that are recognized as essential regulators of relevant molecular mechanisms, including carcinogenesis. Current investigations show that miRNAs are detectable not only in different tissue types but also in a wide...

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Bibliographic Details
Published in:International journal of nanomedicine 2015-01, Vol.10 (default), p.791-800
Main Authors: Braicu, Cornelia, Cojocneanu-Petric, Roxana, Chira, Sergiu, Truta, Anamaria, Floares, Alexandru, Petrut, Bogdan, Achimas-Cadariu, Patriciu, Berindan-Neagoe, Ioana
Format: Article
Language:English
Subjects:
Biomarkers
Bladder cancer
Care and treatment
Cellular biology
diagnostic
Gene Expression Regulation, Neoplastic
Genetic aspects
Genomics
Health risk assessment
Humans
Lymphatic system
Medical prognosis
Medicine
MicroRNA
MicroRNAs
MicroRNAs - genetics
miRNA
Mortality
Oncology
Pharmacy
Physiological aspects
prognostic
Properties
Review
Urinary Bladder Neoplasms - genetics
Urinary Bladder Neoplasms - pathology
Urine
Urology
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Summary:MicroRNAs (miRNAs) are small, noncoding RNA species with a length of 20-22 nucleotides that are recognized as essential regulators of relevant molecular mechanisms, including carcinogenesis. Current investigations show that miRNAs are detectable not only in different tissue types but also in a wide range of biological fluids, either free or trapped in circulating microvesicles. miRNAs were proven to be involved in cell communication, both in pathological and physiological processes. Evaluation of the global expression patterns of miRNAs provides key opportunities with important practical applications, taking into account that they modulate essential biological processes such as epithelial to mesenchymal transition, which is a mechanism relevant in bladder cancer. miRNAs collected from biological specimens can furnish valuable evidence with regard to bladder cancer oncogenesis, as they also have been linked to clinical outcomes in urothelial carcinoma. Therefore, a single miRNA or a signature of multiple miRNAs may improve risk stratification of patients and may supplement the histological diagnosis of urological tumors, particularly for bladder cancer.
ISSN:1178-2013
1176-9114
1178-2013
DOI:10.2147/ijn.s72904