Hydrogels For Peptide Hormones Delivery: Therapeutic And Tissue Engineering Applications

Peptides are the most abundant biological compounds in the cells that act as enzymes, hormones, structural element, and antibodies. Mostly, peptides have problems to move across the cells because of their size and poor cellular penetration. Therefore, a carrier that could transfer peptides into cell...

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Bibliographic Details
Published in:Drug design, development and therapy development and therapy, 2019-09, Vol.13, p.3405-3418
Main Authors: Doostmohammadi, Mohsen, Ameri, Atefeh, Mohammadinejad, Reza, Dehghannoudeh, Negar, Banat, Ibrahim M, Ohadi, Mandana, Dehghannoudeh, Gholamreza
Format: Article
Language:English
Subjects:
Antibodies
Biocompatibility
Biomedical materials
Biopolymers
Cell size
Cholecystokinin
Diabetes
Drug Carriers - chemistry
Drug delivery
Drug Delivery Systems
Drugs
Enzymes
External stimuli
Growth hormones
Health aspects
Hormones
Humans
Hydrogels
Hydrogels - chemistry
Insulin
Lipids
Medical treatment
Menopause
Nanoparticles
Peptide hormones
Peptide Hormones - chemistry
Peptide Hormones - therapeutic use
Peptides
Peptides hormones
Pharmaceutical sciences
Physiology
Polymer industry
Polymers
Polypeptides
Polysaccharides
Proteins
Regenerative Medicine
Review
Saccharides
Stem cells
Structural members
Sustainability
Sustainable development
Tissue Engineering
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Summary:Peptides are the most abundant biological compounds in the cells that act as enzymes, hormones, structural element, and antibodies. Mostly, peptides have problems to move across the cells because of their size and poor cellular penetration. Therefore, a carrier that could transfer peptides into cells is ideal and would be effective for disease treatment. Until now, plenty of polymers, e.g., polysaccharides, polypeptides, and lipids were used in drug delivery. Hydrogels made from polysaccharides showed significant development in targeted delivery of peptide hormones because of their natural characteristics such as networks, pore sizes, sustainability, and response to external stimuli. The main aim of the present review was therefore, to gather the important usages of the hydrogels as a carrier in peptide hormone delivery and their application in tissue engineering and regenerative medicine.
ISSN:1177-8881
1177-8881
DOI:10.2147/DDDT.S217211