The Design, Synthesis, and Characterization of Resveratrol Derivatives Modified by Different γ-Aminobutyric Acid Esters

A novel series of resveratrol modified by γ-aminobutyric acid esters were designed and synthesized. Then, the products were characterized by 1H-NMR, 13C-NMR, and MS, and the melting point was determined. Molecular water solubility, polar surface area, and octanol-water partition were calculated, whi...

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Bibliographic Details
Published in:Journal of chemistry 2019, Vol.2019 (2019), p.1-6
Main Authors: Zhang, Rui Xia, Wang, Yu Ying, Huang, Shao Yun, Wang, Zhizhong, Ge, Hu Rong, Liu, Jia Yue, Tian, Bing Ren, Huang, Qing
Format: Article
Language:English
Subjects:
Amino acids
Brain research
Cardiovascular disease
Chromatography
Computational chemistry
Design modifications
Esters
Food
Laboratories
Melting points
NMR
Nuclear magnetic resonance
Octanol
Pharmaceutical sciences
Software
Solvents
Transport properties
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Summary:A novel series of resveratrol modified by γ-aminobutyric acid esters were designed and synthesized. Then, the products were characterized by 1H-NMR, 13C-NMR, and MS, and the melting point was determined. Molecular water solubility, polar surface area, and octanol-water partition were calculated, which correlated well with molecular transport through membranes and, therefore, enabled prediction of transport properties of drugs.
ISSN:2090-9063
2090-9071
DOI:10.1155/2019/3050486