Evaluating Circulating Biomarkers for Diagnosis, Prognosis, and Tumor Monitoring in Pediatric Sarcomas: Recent Advances and Future Directions

Pediatric sarcomas present a significant challenge in oncology. There is an urgent need for improved therapeutic strategies for high-risk patients and better management of long-term side effects for those who survive the disease. Liquid biopsy is emerging as a promising tool to optimize treatment in...

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Bibliographic Details
Published in:Biomolecules (Basel, Switzerland) Switzerland), 2024-10, Vol.14 (10), p.1306
Main Authors: Maqueda, Joaquín J, De Feo, Alessandra, Scotlandi, Katia
Format: Article
Language:English
Subjects:
Biological markers
Biomarkers
Biomarkers, Tumor - blood
Biopsy
Bone Neoplasms - blood
Bone Neoplasms - diagnosis
Cancer therapies
Cell cycle
Chemotherapy
Child
Chromosomes
Diagnosis
Epigenetics
Ewing's sarcoma
Ewings sarcoma
Genes
Genomes
Humans
Identification and classification
liquid biopsies
Liquid Biopsy - methods
Metastasis
Mutation
Osteosarcoma
Osteosarcoma - blood
Osteosarcoma - diagnosis
Patients
pediatric sarcomas
Pediatrics
Physiological aspects
Prognosis
Proteins
Radiation
Review
Rhabdomyosarcoma
Rhabdomyosarcoma - blood
Rhabdomyosarcoma - diagnosis
Risk groups
Sarcoma
Sarcoma - blood
Sarcoma - diagnosis
Sarcoma, Ewing - blood
Sarcoma, Ewing - diagnosis
Transcription factors
Tumors
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Summary:Pediatric sarcomas present a significant challenge in oncology. There is an urgent need for improved therapeutic strategies for high-risk patients and better management of long-term side effects for those who survive the disease. Liquid biopsy is emerging as a promising tool to optimize treatment in these patients by offering non-invasive, repeatable assessments of disease status. Circulating biomarkers can provide valuable insights into tumor genetics and treatment response, potentially facilitating early diagnosis and dynamic disease monitoring. This review examines the potential of liquid biopsies, focusing on circulating biomarkers in the most common pediatric sarcomas, i.e., osteosarcoma, Ewing sarcoma, and rhabdomyosarcoma. We also highlight the current research efforts and the necessary advancements required before these technologies can be widely adopted in clinical practice.
ISSN:2218-273X
2218-273X
DOI:10.3390/biom14101306