Evaluating Circulating Biomarkers for Diagnosis, Prognosis, and Tumor Monitoring in Pediatric Sarcomas: Recent Advances and Future Directions

Pediatric sarcomas present a significant challenge in oncology. There is an urgent need for improved therapeutic strategies for high-risk patients and better management of long-term side effects for those who survive the disease. Liquid biopsy is emerging as a promising tool to optimize treatment in...

Full description

Saved in:
Bibliographic Details
Published in:Biomolecules (Basel, Switzerland) Switzerland), 2024-10, Vol.14 (10), p.1306
Main Authors: Maqueda, Joaquín J, De Feo, Alessandra, Scotlandi, Katia
Format: Article
Language:English
Subjects:
Biological markers
Biomarkers
Biomarkers, Tumor - blood
Biopsy
Bone Neoplasms - blood
Bone Neoplasms - diagnosis
Cancer therapies
Cell cycle
Chemotherapy
Child
Chromosomes
Diagnosis
Epigenetics
Ewing's sarcoma
Ewings sarcoma
Genes
Genomes
Humans
Identification and classification
liquid biopsies
Liquid Biopsy - methods
Metastasis
Mutation
Osteosarcoma
Osteosarcoma - blood
Osteosarcoma - diagnosis
Patients
pediatric sarcomas
Pediatrics
Physiological aspects
Prognosis
Proteins
Radiation
Review
Rhabdomyosarcoma
Rhabdomyosarcoma - blood
Rhabdomyosarcoma - diagnosis
Risk groups
Sarcoma
Sarcoma - blood
Sarcoma - diagnosis
Sarcoma, Ewing - blood
Sarcoma, Ewing - diagnosis
Transcription factors
Tumors
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by
cites cdi_FETCH-LOGICAL-c395t-6d51243f3f048b40e334bd7763ec0d863bb06207532643a243e91a202ddb46863
container_end_page
container_issue 10
container_start_page 1306
container_title Biomolecules (Basel, Switzerland)
container_volume 14
creator Maqueda, Joaquín J
De Feo, Alessandra
Scotlandi, Katia
description Pediatric sarcomas present a significant challenge in oncology. There is an urgent need for improved therapeutic strategies for high-risk patients and better management of long-term side effects for those who survive the disease. Liquid biopsy is emerging as a promising tool to optimize treatment in these patients by offering non-invasive, repeatable assessments of disease status. Circulating biomarkers can provide valuable insights into tumor genetics and treatment response, potentially facilitating early diagnosis and dynamic disease monitoring. This review examines the potential of liquid biopsies, focusing on circulating biomarkers in the most common pediatric sarcomas, i.e., osteosarcoma, Ewing sarcoma, and rhabdomyosarcoma. We also highlight the current research efforts and the necessary advancements required before these technologies can be widely adopted in clinical practice.
doi_str_mv 10.3390/biom14101306
format article
fullrecord <record><control><sourceid>gale_doaj_</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_09e36ea094b6488e9b3de96ff8ef858f</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A814384134</galeid><doaj_id>oai_doaj_org_article_09e36ea094b6488e9b3de96ff8ef858f</doaj_id><sourcerecordid>A814384134</sourcerecordid><originalsourceid>FETCH-LOGICAL-c395t-6d51243f3f048b40e334bd7763ec0d863bb06207532643a243e91a202ddb46863</originalsourceid><addsrcrecordid>eNptklFv0zAQgCMEYtPYG88oEi88rJudc1ybF1TKxiYNMcGQeLMc-1JcUnuzk0r8CP4zzrqNFuFY8sn33ReddUXxkpJjAElOGhdWlFFCgfAnxX5VUTGppvD96Va8VxymtCR5ibwreF7sgWQ1r0DuF79P17obdO_8opy7aIZuE7_PYh1_YkxlG2L5wemFD8mlo_IqhodQe1teD6uc_xS860McK50vr9A63Udnyq86mixKb8svaND35cyutTeY7mrPhn6ImOURTe-CTy-KZ63uEh7enwfFt7PT6_n55PLzx4v57HJiQNb9hNuaVgxaaAkTDSMIwBo7nXJAQ6zg0DSEV2RaQ8UZ6IyipLoilbUN4zl_UFxsvDbopbqJLvf6SwXt1N1FiAulY-9Mh4pIBI6aSNZwJgTKBixK3rYCW1GLNrvebVw3Q7NCO3YZdbcj3c1490MtwlpRWhM-pTIb3twbYrgdMPVq5ZLBrtMew5AU0IqSWlIxoq__QZdhiD6_1UiRugZWk7_UQucOnG9D_rEZpWomKAPBKLBMHf-Hyp_FlTPBY-vy_U7B0abAxJBSxPaxSUrUOI5qexwz_mr7YR7hh-GDP0oL2nM</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3120553450</pqid></control><display><type>article</type><title>Evaluating Circulating Biomarkers for Diagnosis, Prognosis, and Tumor Monitoring in Pediatric Sarcomas: Recent Advances and Future Directions</title><source>Access via ProQuest (Open Access)</source><source>PubMed Central</source><creator>Maqueda, Joaquín J ; De Feo, Alessandra ; Scotlandi, Katia</creator><creatorcontrib>Maqueda, Joaquín J ; De Feo, Alessandra ; Scotlandi, Katia</creatorcontrib><description>Pediatric sarcomas present a significant challenge in oncology. There is an urgent need for improved therapeutic strategies for high-risk patients and better management of long-term side effects for those who survive the disease. Liquid biopsy is emerging as a promising tool to optimize treatment in these patients by offering non-invasive, repeatable assessments of disease status. Circulating biomarkers can provide valuable insights into tumor genetics and treatment response, potentially facilitating early diagnosis and dynamic disease monitoring. This review examines the potential of liquid biopsies, focusing on circulating biomarkers in the most common pediatric sarcomas, i.e., osteosarcoma, Ewing sarcoma, and rhabdomyosarcoma. We also highlight the current research efforts and the necessary advancements required before these technologies can be widely adopted in clinical practice.</description><identifier>ISSN: 2218-273X</identifier><identifier>EISSN: 2218-273X</identifier><identifier>DOI: 10.3390/biom14101306</identifier><identifier>PMID: 39456239</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Biological markers ; Biomarkers ; Biomarkers, Tumor - blood ; Biopsy ; Bone Neoplasms - blood ; Bone Neoplasms - diagnosis ; Cancer therapies ; Cell cycle ; Chemotherapy ; Child ; Chromosomes ; Diagnosis ; Epigenetics ; Ewing's sarcoma ; Ewings sarcoma ; Genes ; Genomes ; Humans ; Identification and classification ; liquid biopsies ; Liquid Biopsy - methods ; Metastasis ; Mutation ; Osteosarcoma ; Osteosarcoma - blood ; Osteosarcoma - diagnosis ; Patients ; pediatric sarcomas ; Pediatrics ; Physiological aspects ; Prognosis ; Proteins ; Radiation ; Review ; Rhabdomyosarcoma ; Rhabdomyosarcoma - blood ; Rhabdomyosarcoma - diagnosis ; Risk groups ; Sarcoma ; Sarcoma - blood ; Sarcoma - diagnosis ; Sarcoma, Ewing - blood ; Sarcoma, Ewing - diagnosis ; Transcription factors ; Tumors</subject><ispartof>Biomolecules (Basel, Switzerland), 2024-10, Vol.14 (10), p.1306</ispartof><rights>COPYRIGHT 2024 MDPI AG</rights><rights>2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2024 by the authors. 2024</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c395t-6d51243f3f048b40e334bd7763ec0d863bb06207532643a243e91a202ddb46863</cites><orcidid>0000-0001-6114-9499 ; 0000-0002-0800-4167 ; 0000-0002-9805-1361</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/3120553450/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/3120553450?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,44590,53791,53793,75126</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39456239$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Maqueda, Joaquín J</creatorcontrib><creatorcontrib>De Feo, Alessandra</creatorcontrib><creatorcontrib>Scotlandi, Katia</creatorcontrib><title>Evaluating Circulating Biomarkers for Diagnosis, Prognosis, and Tumor Monitoring in Pediatric Sarcomas: Recent Advances and Future Directions</title><title>Biomolecules (Basel, Switzerland)</title><addtitle>Biomolecules</addtitle><description>Pediatric sarcomas present a significant challenge in oncology. There is an urgent need for improved therapeutic strategies for high-risk patients and better management of long-term side effects for those who survive the disease. Liquid biopsy is emerging as a promising tool to optimize treatment in these patients by offering non-invasive, repeatable assessments of disease status. Circulating biomarkers can provide valuable insights into tumor genetics and treatment response, potentially facilitating early diagnosis and dynamic disease monitoring. This review examines the potential of liquid biopsies, focusing on circulating biomarkers in the most common pediatric sarcomas, i.e., osteosarcoma, Ewing sarcoma, and rhabdomyosarcoma. We also highlight the current research efforts and the necessary advancements required before these technologies can be widely adopted in clinical practice.</description><subject>Biological markers</subject><subject>Biomarkers</subject><subject>Biomarkers, Tumor - blood</subject><subject>Biopsy</subject><subject>Bone Neoplasms - blood</subject><subject>Bone Neoplasms - diagnosis</subject><subject>Cancer therapies</subject><subject>Cell cycle</subject><subject>Chemotherapy</subject><subject>Child</subject><subject>Chromosomes</subject><subject>Diagnosis</subject><subject>Epigenetics</subject><subject>Ewing's sarcoma</subject><subject>Ewings sarcoma</subject><subject>Genes</subject><subject>Genomes</subject><subject>Humans</subject><subject>Identification and classification</subject><subject>liquid biopsies</subject><subject>Liquid Biopsy - methods</subject><subject>Metastasis</subject><subject>Mutation</subject><subject>Osteosarcoma</subject><subject>Osteosarcoma - blood</subject><subject>Osteosarcoma - diagnosis</subject><subject>Patients</subject><subject>pediatric sarcomas</subject><subject>Pediatrics</subject><subject>Physiological aspects</subject><subject>Prognosis</subject><subject>Proteins</subject><subject>Radiation</subject><subject>Review</subject><subject>Rhabdomyosarcoma</subject><subject>Rhabdomyosarcoma - blood</subject><subject>Rhabdomyosarcoma - diagnosis</subject><subject>Risk groups</subject><subject>Sarcoma</subject><subject>Sarcoma - blood</subject><subject>Sarcoma - diagnosis</subject><subject>Sarcoma, Ewing - blood</subject><subject>Sarcoma, Ewing - diagnosis</subject><subject>Transcription factors</subject><subject>Tumors</subject><issn>2218-273X</issn><issn>2218-273X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNptklFv0zAQgCMEYtPYG88oEi88rJudc1ybF1TKxiYNMcGQeLMc-1JcUnuzk0r8CP4zzrqNFuFY8sn33ReddUXxkpJjAElOGhdWlFFCgfAnxX5VUTGppvD96Va8VxymtCR5ibwreF7sgWQ1r0DuF79P17obdO_8opy7aIZuE7_PYh1_YkxlG2L5wemFD8mlo_IqhodQe1teD6uc_xS860McK50vr9A63Udnyq86mixKb8svaND35cyutTeY7mrPhn6ImOURTe-CTy-KZ63uEh7enwfFt7PT6_n55PLzx4v57HJiQNb9hNuaVgxaaAkTDSMIwBo7nXJAQ6zg0DSEV2RaQ8UZ6IyipLoilbUN4zl_UFxsvDbopbqJLvf6SwXt1N1FiAulY-9Mh4pIBI6aSNZwJgTKBixK3rYCW1GLNrvebVw3Q7NCO3YZdbcj3c1490MtwlpRWhM-pTIb3twbYrgdMPVq5ZLBrtMew5AU0IqSWlIxoq__QZdhiD6_1UiRugZWk7_UQucOnG9D_rEZpWomKAPBKLBMHf-Hyp_FlTPBY-vy_U7B0abAxJBSxPaxSUrUOI5qexwz_mr7YR7hh-GDP0oL2nM</recordid><startdate>20241016</startdate><enddate>20241016</enddate><creator>Maqueda, Joaquín J</creator><creator>De Feo, Alessandra</creator><creator>Scotlandi, Katia</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7TM</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0001-6114-9499</orcidid><orcidid>https://orcid.org/0000-0002-0800-4167</orcidid><orcidid>https://orcid.org/0000-0002-9805-1361</orcidid></search><sort><creationdate>20241016</creationdate><title>Evaluating Circulating Biomarkers for Diagnosis, Prognosis, and Tumor Monitoring in Pediatric Sarcomas: Recent Advances and Future Directions</title><author>Maqueda, Joaquín J ; De Feo, Alessandra ; Scotlandi, Katia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c395t-6d51243f3f048b40e334bd7763ec0d863bb06207532643a243e91a202ddb46863</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Biological markers</topic><topic>Biomarkers</topic><topic>Biomarkers, Tumor - blood</topic><topic>Biopsy</topic><topic>Bone Neoplasms - blood</topic><topic>Bone Neoplasms - diagnosis</topic><topic>Cancer therapies</topic><topic>Cell cycle</topic><topic>Chemotherapy</topic><topic>Child</topic><topic>Chromosomes</topic><topic>Diagnosis</topic><topic>Epigenetics</topic><topic>Ewing's sarcoma</topic><topic>Ewings sarcoma</topic><topic>Genes</topic><topic>Genomes</topic><topic>Humans</topic><topic>Identification and classification</topic><topic>liquid biopsies</topic><topic>Liquid Biopsy - methods</topic><topic>Metastasis</topic><topic>Mutation</topic><topic>Osteosarcoma</topic><topic>Osteosarcoma - blood</topic><topic>Osteosarcoma - diagnosis</topic><topic>Patients</topic><topic>pediatric sarcomas</topic><topic>Pediatrics</topic><topic>Physiological aspects</topic><topic>Prognosis</topic><topic>Proteins</topic><topic>Radiation</topic><topic>Review</topic><topic>Rhabdomyosarcoma</topic><topic>Rhabdomyosarcoma - blood</topic><topic>Rhabdomyosarcoma - diagnosis</topic><topic>Risk groups</topic><topic>Sarcoma</topic><topic>Sarcoma - blood</topic><topic>Sarcoma - diagnosis</topic><topic>Sarcoma, Ewing - blood</topic><topic>Sarcoma, Ewing - diagnosis</topic><topic>Transcription factors</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Maqueda, Joaquín J</creatorcontrib><creatorcontrib>De Feo, Alessandra</creatorcontrib><creatorcontrib>Scotlandi, Katia</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Biological Sciences</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Biological Science Database</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Biomolecules (Basel, Switzerland)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Maqueda, Joaquín J</au><au>De Feo, Alessandra</au><au>Scotlandi, Katia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluating Circulating Biomarkers for Diagnosis, Prognosis, and Tumor Monitoring in Pediatric Sarcomas: Recent Advances and Future Directions</atitle><jtitle>Biomolecules (Basel, Switzerland)</jtitle><addtitle>Biomolecules</addtitle><date>2024-10-16</date><risdate>2024</risdate><volume>14</volume><issue>10</issue><spage>1306</spage><pages>1306-</pages><issn>2218-273X</issn><eissn>2218-273X</eissn><abstract>Pediatric sarcomas present a significant challenge in oncology. There is an urgent need for improved therapeutic strategies for high-risk patients and better management of long-term side effects for those who survive the disease. Liquid biopsy is emerging as a promising tool to optimize treatment in these patients by offering non-invasive, repeatable assessments of disease status. Circulating biomarkers can provide valuable insights into tumor genetics and treatment response, potentially facilitating early diagnosis and dynamic disease monitoring. This review examines the potential of liquid biopsies, focusing on circulating biomarkers in the most common pediatric sarcomas, i.e., osteosarcoma, Ewing sarcoma, and rhabdomyosarcoma. We also highlight the current research efforts and the necessary advancements required before these technologies can be widely adopted in clinical practice.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>39456239</pmid><doi>10.3390/biom14101306</doi><orcidid>https://orcid.org/0000-0001-6114-9499</orcidid><orcidid>https://orcid.org/0000-0002-0800-4167</orcidid><orcidid>https://orcid.org/0000-0002-9805-1361</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 2218-273X
ispartof Biomolecules (Basel, Switzerland), 2024-10, Vol.14 (10), p.1306
issn 2218-273X
2218-273X
language eng
recordid cdi_doaj_primary_oai_doaj_org_article_09e36ea094b6488e9b3de96ff8ef858f
source Access via ProQuest (Open Access); PubMed Central
subjects Biological markers
Biomarkers
Biomarkers, Tumor - blood
Biopsy
Bone Neoplasms - blood
Bone Neoplasms - diagnosis
Cancer therapies
Cell cycle
Chemotherapy
Child
Chromosomes
Diagnosis
Epigenetics
Ewing's sarcoma
Ewings sarcoma
Genes
Genomes
Humans
Identification and classification
liquid biopsies
Liquid Biopsy - methods
Metastasis
Mutation
Osteosarcoma
Osteosarcoma - blood
Osteosarcoma - diagnosis
Patients
pediatric sarcomas
Pediatrics
Physiological aspects
Prognosis
Proteins
Radiation
Review
Rhabdomyosarcoma
Rhabdomyosarcoma - blood
Rhabdomyosarcoma - diagnosis
Risk groups
Sarcoma
Sarcoma - blood
Sarcoma - diagnosis
Sarcoma, Ewing - blood
Sarcoma, Ewing - diagnosis
Transcription factors
Tumors
title Evaluating Circulating Biomarkers for Diagnosis, Prognosis, and Tumor Monitoring in Pediatric Sarcomas: Recent Advances and Future Directions
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-20T16%3A40%3A09IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_doaj_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Evaluating%20Circulating%20Biomarkers%20for%20Diagnosis,%20Prognosis,%20and%20Tumor%20Monitoring%20in%20Pediatric%20Sarcomas:%20Recent%20Advances%20and%20Future%20Directions&rft.jtitle=Biomolecules%20(Basel,%20Switzerland)&rft.au=Maqueda,%20Joaqu%C3%ADn%20J&rft.date=2024-10-16&rft.volume=14&rft.issue=10&rft.spage=1306&rft.pages=1306-&rft.issn=2218-273X&rft.eissn=2218-273X&rft_id=info:doi/10.3390/biom14101306&rft_dat=%3Cgale_doaj_%3EA814384134%3C/gale_doaj_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c395t-6d51243f3f048b40e334bd7763ec0d863bb06207532643a243e91a202ddb46863%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=3120553450&rft_id=info:pmid/39456239&rft_galeid=A814384134&rfr_iscdi=true