A Systematic Review of Orthosiphon stamineus Benth. in the Treatment of Diabetes and Its Complications

• Published in: Molecules (Basel, Switzerland) Switzerland), 2022-01, Vol.27 (2), p.444
• Main Authors: Wang, Qirou, Wang, Jia, Li, Nannan, Liu, Junyu, Zhou, Jingna, Zhuang, Pengwei, Chen, Haixia
• Format: Article
• Language: English
• Subjects: antidiabetic mechanisms; Antidiabetics; Antioxidants; Complications; Diabetes; Diabetes Complications - drug therapy; Diabetes mellitus; Diabetes Mellitus - drug therapy; Diabetes Mellitus - metabolism; diabetic complications; Diabetic neuropathy; Diabetic retinopathy; Ethanol; Flavonoids; Free radicals; Glucagon; Gluconeogenesis; Glucose; Glucosidase; Glycolysis; Humans; Hyperglycemia; Hypoglycemia; hypoglycemic activity; Hypoglycemic Agents - adverse effects; Hypoglycemic Agents - chemistry; Hypoglycemic Agents - pharmacokinetics; Hypoglycemic Agents - pharmacology; Inflammation; Insulin; Insulin Resistance; Insulin secretion; Lipid metabolism; Lipid Metabolism - drug effects; Lipids; Literature reviews; Medicine, East Asian Traditional; Metabolic disorders; Metabolism; Natural products; Orthosiphon - chemistry; Orthosiphon stamineus; Pharmacodynamics; Pharmacology; Phenolic acids; Phenols; Phytochemicals; Plant Extracts - chemistry; Plant Extracts - pharmacology; Plants, Medicinal - chemistry; Renal failure; Review; Secretion; Systematic review; Toxicology; Triterpenoids; α-Amylase; α-Glucosidase
• ISSN: 1420-3049; 1420-3049
• DOI: 10.3390/molecules27020444

(1) Background: Benth. is a traditional medicine used in the treatment of diabetes and chronic renal failure in southern China, Malaysia, and Thailand. Diabetes is a chronic metabolic disease and the number of diabetic patients in the world is increasing. This review aimed to systematically review the effects of in the treatment of diabetes and its complications and the pharmacodynamic material basis. (2) Methods: This systematic review was conducted following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA), using the databases ScienceDirect, PubMed, and Web of Science. (3) Results: Thirty-one articles related to and diabetes were included. The mechanisms of in the treatment of diabetes and its complications mainly included inhibiting α-amylase and α-glucosidase activities, antioxidant and anti-inflammatory activities, regulating lipid metabolism, promoting insulin secretion, ameliorating insulin resistance, increasing glucose uptake, promoting glycolysis, inhibiting gluconeogenesis, promoting glucagon-likepeptide-1 (GLP-1) secretion and antiglycation activity. Phenolic acids, flavonoids and triterpenoids might be the main components for hypoglycemia effects in . (4) Conclusion: could be an antidiabetic agent to treat diabetes and its complications. However, it needs further study on a pharmacodynamic substance basis and the mechanisms of effective constituents.