Sex Differences in the Behavioural Outcomes of Prenatal Nicotine and Tobacco Exposure

Smoking remains the leading cause of preventable death worldwide. A combination of biological and environmental risk factors make women especially vulnerable to nicotine addiction, making it harder for them to quit smoking. Smoking during pregnancy, therefore, is still a major health concern, with e...

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Bibliographic Details
Published in:Frontiers in neuroscience 2022-07, Vol.16, p.921429
Main Authors: Sikic, Anita, Frie, Jude A, Khokhar, Jibran Y, Murray, Jennifer E
Format: Article
Language:English
Subjects:
Addictions
Cigarettes
cognition
Cognition & reasoning
Drinking water
Electronic cigarettes
Epidemiology
Females
Gender differences
Males
Neuroscience
Nicotine
Pregnancy
prenatal
Prenatal experience
Risk factors
Rodents
sex
Sex differences
Smoking
Tobacco
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Summary:Smoking remains the leading cause of preventable death worldwide. A combination of biological and environmental risk factors make women especially vulnerable to nicotine addiction, making it harder for them to quit smoking. Smoking during pregnancy, therefore, is still a major health concern, with epidemiological data suggesting a role for gestational nicotine exposure in the development of several behavioural disorders. Given there are significant sex-specific behavioural outcomes related to smoking in adolescence and adulthood, it is probable that the behavioural outcomes following gestational nicotine or tobacco exposure are similarly sex-dependent. This is an especially relevant topic as the current landscape of nicotine use shifts toward vaping, a mode of high doses of nicotine delivery that is largely believed to be a safer alternative to cigarettes among the public as well as among pregnant women. Here we review existing clinical and preclinical findings regarding the sex-dependent behavioural outcomes of prenatal nicotine exposure. We also highlight the challenges within this literature, particularly those areas in which further research is necessary to improve consistency within, and between, clinical and preclinical findings.
ISSN:1662-4548
1662-453X
1662-453X
DOI:10.3389/fnins.2022.921429