Green tea influence on iron overload in thalassemia intermedia patients: a randomized controlled trial

Although iron chelation therapies have been available for many years for thalassemia intermedia patients, iron accumulation remains the major cause of death. Therefore, the need for additional chelation options is in demand. This randomized controlled study aimed to understand the effects of green t...

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Bibliographic Details
Published in:F1000 research 2020, Vol.9, p.1136-1136
Main Authors: Al-Momen, Hayder, Hussein, Hussein Khudhair, Al-Attar, Zaid, Hussein, Mohammed Jalal
Format: Article
Language:English
Subjects:
Anemia
Benzoates
beta-Thalassemia - complications
beta-Thalassemia - drug therapy
Blood
Blood diseases
Blood transfusion
Blood transfusions
Body mass index
Chelation
Chelation therapy
Clinical trials
Deferasirox
Demography
Drug dosages
Dry weight
Ethics
Ferritin
Green tea
Hemoglobin
Humans
Iron
Iron Chelating Agents - therapeutic use
Iron Overload - drug therapy
Iron Overload - etiology
Laboratories
Liver
Magnetic resonance imaging
Meals
Patients
Polyphenols
Tea
Thalassemia
Triazoles
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Summary:Although iron chelation therapies have been available for many years for thalassemia intermedia patients, iron accumulation remains the major cause of death. Therefore, the need for additional chelation options is in demand. This randomized controlled study aimed to understand the effects of green tea on iron balance in thalassemia intermedia patients. Using a random selection method, 141 thalassemia intermedia patients were initially screened for inclusion in this trial; only 68 patients included after applying exclusion criteria. Two equal groups were generated (n=34/group): green tea (three cups/day after meals) + usual treatment (deferasirox iron chelator and on demand blood transfusion); and control (only usual treatment). The study lasted for a period of 12 months. Patients failing to comply to the trial methodology were excluded, leaving a final total of 29 patients in the green tea group and 28 patients in the control group. Liver iron concentration, and serum ferritin were assessed at baseline and 12 months, while hemoglobin levels were assessed monthly. At baseline, both groups were matched regarding general demographics. At 12 months, the net drop of liver iron concentration in the green tea group (7.3 mg Fe/g dry weight) was significantly higher than the control group (4.6 mg Fe/g dry weight) (p
ISSN:2046-1402
2046-1402
DOI:10.12688/f1000research.25553.1