Relevance of target-organ lesions as predictors of mortality in patients with diabetes mellitus

• Published in: Arquivos brasileiros de cardiologia 2014-10, Vol.103 (4), p.272-281
• Main Authors: Bianco, Henrique Tria, Izar, Maria Cristina, Fonseca, Henrique Andrade, Póvoa, Rui Manuel, Saraiva, José Francisco, Forti, Adriana, Jardim, Paulo Cesar B V, Introcaso, Luis, Yugar-Toledo, Juan, Xavier, Hermes Tóros, Faludi, André Arpad, Fonseca, Francisco A H
• Format: Article
• Language: English
• Subjects: Aged; Brazil; CARDIAC & CARDIOVASCULAR SYSTEMS; Cardiovascular Diseases - etiology; Cardiovascular Diseases - mortality; Cohort Studies; Diabetes Mellitus Tipo 2 / complicações; Diabetes Mellitus Tipo 2 / mortalidade; Diabetes Mellitus, Type 2 - complications; Diabetes Mellitus, Type 2 - mortality; Electrocardiography; Epidemiologia; Female; Glomerular Filtration Rate; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Obesity - complications; Obesity - mortality; Original; Predictive Value of Tests; Prognosis; Renal Insufficiency - mortality; Risk Assessment; Risk Factors; Statistics, Nonparametric
• ISSN: 0066-782X; 1678-4170; 1678-4170
• DOI: 10.5935/abc.20140112

Patients with diabetes are in extract higher risk for fatal cardiovascular events. To evaluate major predictors of mortality in subjects with type 2 diabetes. A cohort of 323 individuals with type 2 diabetes from several regions of Brazil was followed for a long period. Baseline electrocardiograms, clinical and laboratory data obtained were used to determine hazard ratios (HR) and confidence interval (CI) related to cardiovascular and total mortality. After 9.2 years of follow-up (median), 33 subjects died (17 from cardiovascular causes). Cardiovascular mortality was associated with male gender; smoking; prior myocardial infarction; long QTc interval; left ventricular hypertrophy; and eGFR