Immune response induced by standard and fractional doses of 17DD yellow fever vaccine

The re-emergence of yellow fever (YF) urged new mass vaccination campaigns and, in 2017, the World Health Organization approved the use of the fractional dose (FD) of the YF vaccine due to stock shortage. In an observational cross-sectional investigation, we have assessed viremia, antibodies, solubl...

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Bibliographic Details
Published in:npj vaccines 2024-03, Vol.9 (1), p.54-54, Article 54
Main Authors: Abdala-Torres, Thais, Campi-Azevedo, Ana Carolina, da Silva-Pereira, Rosiane Aparecida, dos Santos, Luara Isabela, Henriques, Priscilla Miranda, Costa-Rocha, Ismael Artur, Otta, Dayane Andriotti, Peruhype-Magalhães, Vanessa, Teixeira-Carvalho, Andréa, Araújo, Márcio Sobreira Silva, Fernandes, Eder Gatti, Sato, Helena Keico, Fantinato, Francieli Fontana Sutile Tardetti, Domingues, Carla Magda Allan Santos, Kallás, Esper Georges, Tomiyama, Helena Tomoko Iwashita, Lemos, Jandira Aparecida Campos, Coelho-dos-Reis, Jordana Grazziela, de Lima, Sheila Maria Barbosa, Schwarcz, Waleska Dias, de Souza Azevedo, Adriana, Trindade, Gisela Freitas, Ano Bom, Ana Paula Dinis, da Silva, Andrea Marques Vieira, Fernandes, Camilla Bayma, Camacho, Luiz Antônio Bastos, de Sousa Maia, Maria de Lourdes, Martins-Filho, Olindo Assis, do Antonelli, Lis Ribeiro do Valle
Format: Article
Language:English
Subjects:
631/250/2152/1566
631/250/2152/2153
631/250/590/1867
Antibodies
Biomedical and Life Sciences
Biomedicine
Chemokines
Comparative analysis
Cytokines
Epidemics
Fever
Growth factors
Immune response
Immunization
Infectious Diseases
Medical Microbiology
Parasitic diseases
Public Health
Vaccine
Vaccines
Vector-borne diseases
Viral infections
Virology
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Summary:The re-emergence of yellow fever (YF) urged new mass vaccination campaigns and, in 2017, the World Health Organization approved the use of the fractional dose (FD) of the YF vaccine due to stock shortage. In an observational cross-sectional investigation, we have assessed viremia, antibodies, soluble mediators and effector and memory T and B-cells induced by primary vaccination of volunteers with FD and standard dose (SD). Similar viremia and levels of antibodies and soluble markers were induced early after immunization. However, a faster decrease in the latter was observed after SD. The FD led to a sustained expansion of helper T-cells and an increased expression of activation markers on T-cells early after vaccination. Although with different kinetics, expansion of plasma cells was induced upon SD and FD immunization. Integrative analysis reveals that FD induces a more complex network involving follicular helper T cells and B-cells than SD. Our findings substantiate that FD can replace SD inducing robust correlates of protective immune response against YF.
ISSN:2059-0105
2059-0105
DOI:10.1038/s41541-024-00836-w