CCAR2 controls mitotic progression through spatiotemporal regulation of Aurora B

CCAR2 (cell cycle and apoptosis regulator 2) is a multifaceted protein involved in cell survival and death following cytotoxic stress. However, little is known about the physiological functions of CCAR2 in regulating cell proliferation in the absence of external stimuli. The present study shows that...

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Bibliographic Details
Published in:Cell death & disease 2022-06, Vol.13 (6), p.534-534, Article 534
Main Authors: Ryu, Jaewook, Kim, Ja-Eun
Format: Article
Language:English
Subjects:
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Abscission
Anaphase
Antibodies
Apoptosis
Aurora B protein
Aurora Kinase B - genetics
Aurora Kinase B - metabolism
Biochemistry
Biomedical and Life Sciences
Cell Biology
Cell Culture
Cell cycle
Cell Cycle Proteins - metabolism
Cell death
Cell division
Cell growth
Cell proliferation
Cell survival
Centromere - metabolism
Chromosome Segregation
Chromosomes
Cytokinesis
Cytotoxicity
External stimuli
Immunology
Kinases
Life Sciences
Metaphase
Mitosis - genetics
Protein Serine-Threonine Kinases - genetics
Spindle Apparatus - metabolism
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Summary:CCAR2 (cell cycle and apoptosis regulator 2) is a multifaceted protein involved in cell survival and death following cytotoxic stress. However, little is known about the physiological functions of CCAR2 in regulating cell proliferation in the absence of external stimuli. The present study shows that CCAR2-deficient cells possess multilobulated nuclei, suggesting a defect in cell division. In particular, the duration of mitotic phase was perturbed. This disturbance of mitotic progression resulted from premature loss of cohesion with the centromere, and inactivation of the spindle assembly checkpoint during prometaphase and metaphase. It resulted in the formation of lagging chromosomes during anaphase, leading ultimately to the activation of the abscission checkpoint to halt cytokinesis. The CCAR2-dependent mitotic progression was related to spatiotemporal regulation of active Aurora B. In conclusion, the results suggest that CCAR2 governs mitotic events, including proper chromosome segregation and cytokinetic division, to maintain chromosomal stability.
ISSN:2041-4889
2041-4889
DOI:10.1038/s41419-022-04990-8