Bioprospecting Phenols as Inhibitors of Trichothecene-Producing Fusarium : Sustainable Approaches to the Management of Wheat Pathogens

spp. are ubiquitous fungi able to cause Fusarium head blight and Fusarium foot and root rot on wheat. Among relevant pathogenic species, and cause significant yield and quality loss and result in contamination of the grain with mycotoxins, mainly type B trichothecenes, which are a major health conce...

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Bibliographic Details
Published in:Toxins 2022-01, Vol.14 (2), p.72
Main Authors: Chtioui, Wiem, Balmas, Virgilio, Delogu, Giovanna, Migheli, Quirico, Oufensou, Safa
Format: Article
Language:English
Subjects:
Bioprospecting
Biosynthesis
Blight
Cereals
Contamination
Cytochrome
Food
Formulations
Fungicides
Fusarium
Fusarium - drug effects
Fusarium - metabolism
Fusarium graminearum
Fusarium head blight
Genes
Inhibitors
Mycotoxins
Natural products
Pathogens
Pesticides
Phenolic compounds
phenolics
Phenols
Phenols - pharmacology
Population
Review
Root rot
Sustainable development
trichothecene mycotoxins
Trichothecenes
Trichothecenes - metabolism
Trichothecenes - toxicity
Triticum - microbiology
Wheat
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Summary:spp. are ubiquitous fungi able to cause Fusarium head blight and Fusarium foot and root rot on wheat. Among relevant pathogenic species, and cause significant yield and quality loss and result in contamination of the grain with mycotoxins, mainly type B trichothecenes, which are a major health concern for humans and animals. Phenolic compounds of natural origin are being increasingly explored as fungicides on those pathogens. This review summarizes recent research activities related to the antifungal and anti-mycotoxigenic activity of natural phenolic compounds against , including studies into the mechanisms of action of major exogenous phenolic inhibitors, their structure-activity interaction, and the combined effect of these compounds with other natural products or with conventional fungicides in mycotoxin modulation. The role of high-throughput analysis tools to decipher key signaling molecules able to modulate the production of mycotoxins and the development of sustainable formulations enhancing potential inhibitors' efficacy are also discussed.
ISSN:2072-6651
2072-6651
DOI:10.3390/toxins14020072