The genetic variation rs12143842 in NOS1AP increases idiopathic ventricular tachycardia risk in Chinese Han populations

• Published in: Scientific reports 2017-08, Vol.7 (1), p.8356-5, Article 8356
• Main Authors: Zhang, Ronfeng, Chen, Feifei, Yu, Honjiu, Gao, Lianjun, Yin, Xiaomeng, Dong, Yingxue, Yang, Yanzong, Xia, Yunlong
• Format: Article
• Language: English
• Subjects: 45/43; 45/77; 631/208/726/649/2219; 631/208/727/2000; Alleles; Cardiac arrhythmia; Genetic diversity; Genome-wide association studies; Genomes; Genotyping; Humanities and Social Sciences; multidisciplinary; Population studies; Science; Science (multidisciplinary); Single-nucleotide polymorphism; Tachycardia; Ventricle
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-017-08548-z

Genome-wide association studies identified that the common T of rs12143842 in NOS1AP is associated with a QT/QTc interval in European populations. In this study, we test the association between the variation rs12143842 in NOS1AP and idiopathic ventricular tachycardia (IVT). A case-control association study examining rs12143842 was performed in two independent cohorts. The Northern cohort enrolled 277 IVT patients and 728 controls from a Chinese Gene ID population. The Central cohort enrolled 301 IVT patients and 803 matched controls. Genotyping was performed using high-resolution melt analysis. The minor T allele of the rs12143842 SNP was significantly associated with decreased IVT risk in the Northern cohort (adjusted P  = 0.024, OR 0.71(0.52~0.96)), and this association was replicated in an independent Central Gene ID cohort (adjusted P  = 0.029, OR 0.78 (0.62~0.97)). The association was more significant in the combined population (adjusted P  = 0.001, OR 0.76 (0.64~0.90)). The P values for the genotypic association were significant for the dominant ( P