Changes in voice quality, swallowing, and pulmonary function after parathyroidectomy for secondary hyperparathyroidism

• Published in: Asian journal of surgery 2022-11, Vol.45 (11), p.2273-2279
• Main Authors: Chou, Fong-Fu, Chen, Jin-Bor, Huang, Shun-Chen, Chan, Yi-Chia, Chi, Shun-Yu, Lai, Chi-Chih, Wu, Yi-Ju, Chang, Huang-Chih
• Format: Article
• Language: English
• Subjects: O2 desaturation; Parathyroidectomy; Secondary hyperparathyroidism; Swallow; Voice quality
• ISSN: 1015-9584
• DOI: 10.1016/j.asjsur.2021.12.047

To find changes in voice quality, airway invasion during swallowing, pharyngeal residue after swallowing, acoustic and aerodynamic measurements and pulmonary function tests after total parathyroidectomy plus auto-transplantation for secondary hyperparathyroidism. We recruited 38 patients who underwent successful surgery for secondary hyperparathyroidism in this study. Voice quality was evaluated using voice handicap index (VHI-10), eating assessment tool (EAT-10), voice impairment, and the grade, roughness, breathiness, asthenia, strain (GRBAS) scale. Acoustic and aerodynamic measurements included fundamental frequency (F0), maximal phonation time, high pitch, jitter, s/z, shimmer and noise-to-harmonic ratio. Vocal cord mobility, vocal cord closure, premature spillage, the penetration–aspiration scale and the Yale pharyngeal residue severity rating scale (PRSRS) after swallowing were examined using fiber-optic endoscopy. Pulmonary function tests included forced vital capacity, forced expiratory volume in 1 s, bronchodilator test, total lung capacity, diffusion capacity of the lung for carbon monoxide, alveolar volume, and distance and O2 desaturation of the 6 min walking test (6MWT). Four months after successful parathyroidectomy, VHI-10 improved significantly (p