Dissolution Thermodynamics of the Solubility of Sulfamethazine in (Acetonitrile + 1-Propanol) Mixtures

: Solubility is one of the most important parameters in the research and development processes of the pharmaceutical industry. In this context, cosolubility is one of the most used strategies to improve the solubility of poorly soluble drugs, besides allowing to identify some factors involved in the...

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Published in:Pharmaceuticals (Basel, Switzerland) Switzerland), 2024-11, Vol.17 (12), p.1594
Main Authors: Delgado, Daniel Ricardo, Castro-Camacho, Jennifer Katiusca, Ortiz, Claudia Patricia, Caviedes-Rubio, Diego Ivan, Martinez, Fleming
Format: Article
Language:English
Subjects:
1-propanol
Acetonitrile
Chemical industry
cosolvency
Infections
Pharmaceutical industry
solubility
solution thermodynamics
Solvents
sulfamethazine
Temperature
Thermodynamics
Veterinary medicine
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Summary:: Solubility is one of the most important parameters in the research and development processes of the pharmaceutical industry. In this context, cosolubility is one of the most used strategies to improve the solubility of poorly soluble drugs, besides allowing to identify some factors involved in the dissolution process. The aim of this research is to evaluate the solubility of sulfamethazine in acetotinitrile + 1-propanol cosolvent mixtures at 9 temperatures (278.15, 283.15, 288.15, 293.15, 298.15, 303.15, 308.15, 313.15, and 318.15 K); a drug used in human and veterinary therapy and two solvents of great chemical-pharmaceutical interest. : The determination was carried out by the shaking flask method and the drug was quantified by UV/Vis spectrophotometry. : The solubility of sulfamethazine increases from pure 1-propanol (solvent in which it reaches its lowest solubility at 278.15 K) to pure acetonitrile (solvent in which it reaches its maximum solubility at 318.15 K), behaving in a logarithmic-linear fashion. : The increase in solubility is related to the acid/base character of the cosolvent mixtures and not to the solubility parameter of the mixtures. The dissolution process is endothermic and favored by the solution entropy, and also shows a strong entropic compensation.
ISSN:1424-8247
1424-8247
DOI:10.3390/ph17121594