Correlating cognition and cortical excitability with pain in fibromyalgia: a case control study

Fibromyalgia is a chronic pain disorder characterized by widespread musculoskeletal symptoms, primarily attributed to sensitization of somatosensory system carrying pain. Few reports have investigated the impact of fibromyalgia symptoms on cognition, corticomotor excitability, sleepiness, and the sl...

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Bibliographic Details
Published in:Advances in rheumatology (London, England) England), 2021-02, Vol.61 (1), p.10-10, Article 10
Main Authors: Tiwari, Vikas Kumar, Nanda, Srishti, Arya, Suvercha, Kumar, Uma, Sharma, Ratna, Kumaran, Senthil S, Bhatia, Renu
Format: Article
Language:English
Subjects:
Chronic illnesses
Chronic Pain
Cognition
Cognition & reasoning
Cognitive ability
Color
Cross-sectional studies
Daytime
Excitability
Fibromyalgia
Investigations
Laboratories
Menstruation
Motor evoked potentials
Pain
Quality of life
Questionnaires
Reaction Time
Reaction time task
RHEUMATOLOGY
Sleep
Sleep and wakefulness
Somatosensory system
Stroop Test
Transcranial magnetic stimulation
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Summary:Fibromyalgia is a chronic pain disorder characterized by widespread musculoskeletal symptoms, primarily attributed to sensitization of somatosensory system carrying pain. Few reports have investigated the impact of fibromyalgia symptoms on cognition, corticomotor excitability, sleepiness, and the sleep quality - all of which can deteriorate the quality of life in fibromyalgia. However, the existing reports are underpowered and have conflicting directions of findings, limiting their generalizability. Therefore, the present study was designed to compare measures of cognition, corticomotor excitability, sleepiness, and sleep quality using standardized instruments in the recruited patients of fibromyalgia with pain-free controls. Diagnosed cases of fibromyalgia were recruited from the Rheumatology department for the cross-sectional, case-control study. Cognition (Mini-Mental State Examination, Stroop color-word task), corticomotor excitability (Resting motor threshold, Motor evoked potential amplitude), daytime sleepiness (Epworth sleepiness scale), and sleep quality (Pittsburgh sleep quality index) were studied according to the standard procedure. Thirty-four patients of fibromyalgia and 30 pain-free controls were recruited for the study. Patients of fibromyalgia showed decreased cognitive scores (p = 0.05), lowered accuracy in Stroop color-word task (for color: 0.02, for word: 0.01), and prolonged reaction time (
ISSN:2523-3106
2523-3106
DOI:10.1186/s42358-021-00163-x