An Updated Systematic Review of Vaccinium myrtillus Leaves: Phytochemistry and Pharmacology

Bilberry leaves are used in many countries in traditional medicine for treating a wide variety of diseases. Due to the high therapeutic potential of (VM) leaves, this review aims to present the latest knowledge on the phytochemical profile, as well as the therapeutic effects of this herbal drug. The...

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Bibliographic Details
Published in:Pharmaceutics 2022-12, Vol.15 (1), p.16
Main Authors: Ștefănescu, Ruxandra, Laczkó-Zöld, Eszter, Ősz, Bianca-Eugenia, Vari, Camil-Eugen
Format: Article
Language:English
Subjects:
Acids
bilberry
Chemical compounds
Diabetes
Drugs
Ethanol
Flavonoids
Fruits
leaves
Phytochemicals
phytochemistry
Polyphenols
Review
Soil sciences
Systematic review
Vaccinium myrtillus
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Summary:Bilberry leaves are used in many countries in traditional medicine for treating a wide variety of diseases. Due to the high therapeutic potential of (VM) leaves, this review aims to present the latest knowledge on the phytochemical profile, as well as the therapeutic effects of this herbal drug. The review was conducted according to the Prisma guidelines, and the scientific databases were searched using combinations of the following keywords: " ", "leaves", "bilberry". Recent research was focused on the influence of abiotic factors on the phytochemical composition, and it seems that there are significant differences between the herbal drugs collected from different countries. The phytochemical composition is correlated with the broad spectrum of pharmacological effects. The paper outlines the potent antimicrobial activity of VM extracts against multidrug-resistant bacterial strains, and also the pathways that are modulated by the unique "cocktail" of phytoconstituents in different metabolic alterations. Reviewing the research articles published in the last 10 years, it seems that bilberry leaves have been slightly forgotten, although their phytochemical and pharmacological characteristics are unique.
ISSN:1999-4923
1999-4923
DOI:10.3390/pharmaceutics15010016