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Hippocampal-prefrontal theta-gamma coupling during performance of a spatial working memory task
Cross-frequency coupling supports the organization of brain rhythms and is present during a range of cognitive functions. However, little is known about whether and how long-range cross-frequency coupling across distant brain regions subserves working memory. Here we report that theta–slow gamma cou...
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| Published in: | Nature communications 2017-12, Vol.8 (1), p.2182-9, Article 2182 |
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| creator | Tamura, Makoto Spellman, Timothy J. Rosen, Andrew M. Gogos, Joseph A. Gordon, Joshua A. |
| description | Cross-frequency coupling supports the organization of brain rhythms and is present during a range of cognitive functions. However, little is known about whether and how long-range cross-frequency coupling across distant brain regions subserves working memory. Here we report that theta–slow gamma coupling between the hippocampus and medial prefrontal cortex (mPFC) is augmented in a genetic mouse model of cognitive dysfunction. This increased cross-frequency coupling is observed specifically when the mice successfully perform a spatial working memory task. In wild-type mice, increasing task difficulty by introducing a long delay or by optogenetically interfering with encoding, also increases theta–gamma coupling during correct trials. Finally, epochs of high hippocampal theta–prefrontal slow gamma coupling are associated with increased synchronization of neurons within the mPFC. These findings suggest that enhancement of theta–slow gamma coupling reflects a compensatory mechanism to maintain spatial working memory performance in the setting of increased difficulty.
Theta- and gamma-frequency oscillatory synchrony correlates with spatial working memory performance. Here the authors report increases in theta-gamma cross-frequency coupling as a compensatory mechism associated with better working memory performance in models of cognitive dysfunction in mice. |
| doi_str_mv | 10.1038/s41467-017-02108-9 |
| format | article |
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Theta- and gamma-frequency oscillatory synchrony correlates with spatial working memory performance. 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Nature communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tamura, Makoto</au><au>Spellman, Timothy J.</au><au>Rosen, Andrew M.</au><au>Gogos, Joseph A.</au><au>Gordon, Joshua A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hippocampal-prefrontal theta-gamma coupling during performance of a spatial working memory task</atitle><jtitle>Nature communications</jtitle><stitle>Nat Commun</stitle><addtitle>Nat Commun</addtitle><date>2017-12-19</date><risdate>2017</risdate><volume>8</volume><issue>1</issue><spage>2182</spage><epage>9</epage><pages>2182-9</pages><artnum>2182</artnum><issn>2041-1723</issn><eissn>2041-1723</eissn><abstract>Cross-frequency coupling supports the organization of brain rhythms and is present during a range of cognitive functions. However, little is known about whether and how long-range cross-frequency coupling across distant brain regions subserves working memory. Here we report that theta–slow gamma coupling between the hippocampus and medial prefrontal cortex (mPFC) is augmented in a genetic mouse model of cognitive dysfunction. This increased cross-frequency coupling is observed specifically when the mice successfully perform a spatial working memory task. In wild-type mice, increasing task difficulty by introducing a long delay or by optogenetically interfering with encoding, also increases theta–gamma coupling during correct trials. Finally, epochs of high hippocampal theta–prefrontal slow gamma coupling are associated with increased synchronization of neurons within the mPFC. These findings suggest that enhancement of theta–slow gamma coupling reflects a compensatory mechanism to maintain spatial working memory performance in the setting of increased difficulty.
Theta- and gamma-frequency oscillatory synchrony correlates with spatial working memory performance. Here the authors report increases in theta-gamma cross-frequency coupling as a compensatory mechism associated with better working memory performance in models of cognitive dysfunction in mice.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>29259151</pmid><doi>10.1038/s41467-017-02108-9</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-7491-4476</orcidid><orcidid>https://orcid.org/0000-0001-7034-8094</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | 631/378/1595/3922 631/378/1689/1799 631/378/2649/2150 631/378/3920 Animal memory Animals Brain Brain architecture Cognitive ability Cognitive Dysfunction - diagnosis Cognitive Dysfunction - physiopathology Cortical Synchronization - physiology Coupling Disease Models, Animal Electrodes Female Gamma Rhythm - physiology Hippocampus Hippocampus - cytology Hippocampus - physiology Humanities and Social Sciences Humans Male Memory, Short-Term - physiology Mental task performance Mice Mice, Inbred C57BL multidisciplinary Neural Pathways - physiology Neurons - physiology Optogenetics Prefrontal cortex Prefrontal Cortex - cytology Prefrontal Cortex - physiology Rodents Science Science (multidisciplinary) Short term memory Spatial memory Synchronism Synchronization Theta Rhythm - physiology |
| title | Hippocampal-prefrontal theta-gamma coupling during performance of a spatial working memory task |
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