A single arm trial using passive simulated jogging for blunting acute hyperglycemia

• Published in: Scientific reports 2021-03, Vol.11 (1), p.6437-6437, Article 6437
• Main Authors: Adams, Jose A., Lopez, Jose R., Banderas, Veronica, Sackner, Marvin A.
• Format: Article
• Language: English
• Subjects: 631/443/319; 692/308/575; 692/700/459/284; Activities of daily living; Cardiovascular diseases; Cognitive ability; Diabetes mellitus; Feasibility studies; Fluctuations; Glucose; Glucose tolerance; Humanities and Social Sciences; Hyperglycemia; multidisciplinary; NCT; NCT03550105; Oxidative stress; Science; Science (multidisciplinary)
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-021-85579-7

Glycemic fluctuations increase oxidative stress, promote endothelial dysfunction and cardiovascular disease. Reducing glycemic fluctuations is beneficial. We previously reported that a portable motorized passive simulated jogging device, (JD) reduces 24 h glycemic indices in type 2 and non-diabetic subjects. This study evaluates effectiveness and feasibility of JD in blunting large glycemic fluctuation induced by an oral glucose tolerance test (OGTT). The study was performed in 10 adult participants mean age 41.3 ± 13.5 year using interstitial glucose monitor (IG). Each participant fasted for 8 h. followed by an OGTT (Pre-JD), thereafter JD was used for 90 min per day for 7 days, without change to diet or activities of daily living. A repeat OGTT (Post-JD) was performed after completion. The integrated area under the curve (iAUC 2h–4h ) was computed for the OGTT Pre-JD and Post-JD. Seven days of JD blunted the glucose fluctuation produced by OGTT. JD decreased AUC 2h by 17 ± 4.7% and iAUC 4h by 15 ± 5.9% (p