Extremely high levels of central nervous system involvement in miliary tuberculosis

Miliary tuberculosis (TB) is one of the severest manifestations of TB that can be lethal when concomitant with the central nervous system (CNS) involvement. Bacteriological, biochemical and radiological methods for find CNS comorbidity in miliary TB was evaluated in this study. Consecutive miliary T...

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Published in:BMC infectious diseases 2022-04, Vol.22 (1), p.417-417, Article 417
Main Authors: Wang, Guirong, Liang, Ruixia, Sun, Qing, Liao, Xinlei, Wang, Chenqian, Huang, Hairong
Format: Article
Language:English
Subjects:
Adult
Biochemistry
Central nervous system
Central Nervous System - pathology
Cerebrospinal fluid
Complications and side effects
Computed tomography
Consciousness
Development and progression
Diagnosis
Diagnostic tests
Fever
Headaches
Health aspects
HIV
Human immunodeficiency virus
Humans
Infectious diseases
Magnetic Resonance Imaging
Medical imaging
Methods
Miliary
Nervous system
Neuroimaging
Patients
Retrospective Studies
Risk factors (Health)
Sensitivity
Sputum
Statistical analysis
Tuberculosis
Tuberculosis, Miliary - complications
Tuberculosis, Miliary - diagnostic imaging
Vomiting
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Summary:Miliary tuberculosis (TB) is one of the severest manifestations of TB that can be lethal when concomitant with the central nervous system (CNS) involvement. Bacteriological, biochemical and radiological methods for find CNS comorbidity in miliary TB was evaluated in this study. Consecutive miliary TB adults were retrospectively enrolled from two designated TB hospitals in China. The capacities of examinations of cerebrospinal fluid (CSF), cerebral computed tomography (CT) and magnetic resonance imaging (MRI) for diagnosis of CNS involvement were assessed. Assessment of CNS involvement with a lumbar puncture and/or neuroimaging was undertaken in 282 out of 392 of acute miliary TB. Of these 282 patients, 87.59% (247/282) had CNS involvement. Cerebral contrast-enhanced MRI (96.05%, 170/177) and MRI (93.15%, 204/219) yielded significantly higher sensitivities over CSF examination (71.92%, 146/203, P 
ISSN:1471-2334
1471-2334
DOI:10.1186/s12879-022-07390-7