Lifestyle differences between co-twins are associated with decreased similarity in their internal and external exposome profiles

Whether differences in lifestyle between co-twins are reflected in differences in their internal or external exposome profiles remains largely underexplored. We therefore investigated whether within-pair differences in lifestyle were associated with within-pair differences in exposome profiles acros...

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Bibliographic Details
Published in:Scientific reports 2024-09, Vol.14 (1), p.21261-12, Article 21261
Main Authors: Drouard, Gabin, Wang, Zhiyang, Heikkinen, Aino, Foraster, Maria, Julvez, Jordi, Kanninen, Katja M., van Kamp, Irene, Pirinen, Matti, Ollikainen, Miina, Kaprio, Jaakko
Format: Article
Language:English
Subjects:
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Adult
Aging
Algorithms
Datasets
DNA methylation
Drinking behavior
Drug use
Epigenesis, Genetic
Epigenetic age acceleration
Epigenetics
Exposome
Female
Genetics
Health care
Humanities and Social Sciences
Humans
Life Style
Lifestyles
Male
Metabolome
Multi-omics
multidisciplinary
Proteome
Proteome - metabolism
Proteomes
Public health
Risk factors
Science
Science (multidisciplinary)
Social behavior
Substance use
Twin studies
Twins
Twins, Monozygotic
Young Adult
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Summary:Whether differences in lifestyle between co-twins are reflected in differences in their internal or external exposome profiles remains largely underexplored. We therefore investigated whether within-pair differences in lifestyle were associated with within-pair differences in exposome profiles across four domains: the external exposome, proteome, metabolome and epigenetic age acceleration (EAA). For each domain, we assessed the similarity of co-twin profiles using Gaussian similarities in up to 257 young adult same-sex twin pairs (54% monozygotic). We additionally tested whether similarity in one domain translated into greater similarity in another. Results suggest that a lower degree of similarity in co-twins' exposome profiles was associated with greater differences in their behavior and substance use. The strongest association was identified between excessive drinking behavior and the external exposome. Overall, our study demonstrates how social behavior and especially substance use are connected to the internal and external exposomes, while controlling for familial confounders.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-024-72354-7