Antioxidative Flavonol Glucuronides and Anti-HBsAg Flavonol from Rotala rotundifolia

Two new flavonol glucuronides, quercetin 3-O-β-D-2＂-acetylglucuronide (1) and quercetin 3-O-β -D-2＂- acetylglucuronide methyl ester (2), along with four known flavonoids (3-6) were isolated from the whole parts of Rotala rotundifolia. The structures of 1 and 2 were elucidated by application of vario...

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Bibliographic Details
Published in:Journal of Traditional and Complementary Medicine 2011-10, Vol.1 (1), p.57-63
Main Authors: Zhang, Li-Jie, Yeh, Sheau-Farn, Yu, Ya-Ten, Kuo, Li-Ming Yang, Kuo, Yao-Haur
Format: Article
Language:English
Subjects:
Anti-HBsAg
Anti-oxidative activity
Antioxidants
Bioflavonoids
Flavones
Flavonoids
Flavonol glucuronides
Health aspects
Materia medica, Vegetable
Medicinal plants
Original
Pharmacology, Experimental
Plant extracts
Rotala rotundifolia
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Summary:Two new flavonol glucuronides, quercetin 3-O-β-D-2＂-acetylglucuronide (1) and quercetin 3-O-β -D-2＂- acetylglucuronide methyl ester (2), along with four known flavonoids (3-6) were isolated from the whole parts of Rotala rotundifolia. The structures of 1 and 2 were elucidated by application of various spectroscopic methods, including 1D and 2D NMR techniques. Biological evaluation showed that all of isolated flavonoid compounds have potent anti-oxidative activities by DPPH and superoxide anion methods, and kaempferol (3) and quercetin (4) exhibited significant anti-HBV activity assayed by anti-HBsAg production. The HPLC fingerprint with photodiode array detection (HPLC-DAD) for quality control of R. rotundifolia partitioned EtOAc layer was also established.
ISSN:2225-4110
2225-4110
DOI:10.1016/S2225-4110(16)30057-8