ADNP Regulates Cognition: A Multitasking Protein

[...]the SIP domain in NAP interacts with microtubule end binding proteins (EB1 and EB3) enhancing ADNP (Esteves et al., 2014) and tau (Ivashko-Pachima et al., 2017) interaction with microtubules. [...]our original studies have shown that ADNP has a glutaredoxin active site (Bassan et al., 1999). No...

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Bibliographic Details
Published in:Frontiers in neuroscience 2018-11, Vol.12, p.873-873
Main Author: Gozes, Illana
Format: Article
Language:English
Subjects:
ADNP (activity dependent neuroprotective protein)
ADNP gene
ADNP protein
Alzheimer's disease
Autism
Autophagy
Blood levels
Cloning
cognition
Cognition & reasoning
Cognitive ability
Cytoskeleton
Deoxyribonucleic acid
DNA
Genes
Glutaredoxin
Intellectual disabilities
Intelligence
Laboratories
Lymphocytes
Mental disorders
Microtubules
Mutation
neurodegenaration
Neurodegenerative diseases
Neuroscience
protein interaction
Proteins
Schizophrenia
Tau protein
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Summary:[...]the SIP domain in NAP interacts with microtubule end binding proteins (EB1 and EB3) enhancing ADNP (Esteves et al., 2014) and tau (Ivashko-Pachima et al., 2017) interaction with microtubules. [...]our original studies have shown that ADNP has a glutaredoxin active site (Bassan et al., 1999). Notably, the involvement of ADNP in cognitive performance is not limited to the ADNP syndrome but is extended to schizophrenia (Merenlender-Wagner et al., 2015) and Alzheimer's disease (Malishkevich et al., 2016) with ADNP transcripts dysregulated in lymphocytes in both diseases and with ADNP blood levels correlating with intelligence (Malishkevich et al., 2016). [...]the current opinion combines mechanisms to cognitive protection. Furthermore, NAP activity is not limited to the mouse model, but has shown efficacy in amnestic mild cognitive impairment patients, prodromal to Alzheimer's disease (protecting short term memory) and in schizophrenia patients (protecting functional activities of daily living as reviewed; Magen and Gozes, 2013, 2014).
ISSN:1662-4548
1662-453X
1662-453X
DOI:10.3389/fnins.2018.00873