Erythema nodosum revealing acute myeloid leukemia

Introduction: Erythema nodosum (EN) is the most common type of panniculitis. It may be idiopathic or secondary to various etiologies. However, the occurrence of erythema nodosum in malignant hemopathy had rarely been reported. Case report: A 42 year-old woman presented with a four week history of re...

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Bibliographic Details
Published in:Nasza dermatologia online 2013-07, Vol.4 (3), p.333-334
Main Authors: Wafa, Chebbi, Faida, Ajili, Najeh, Boussetta, Fatma, Abderrezak, Salah, Othmani, Habib, Sfar Mohamed
Format: Article
Language:English
Subjects:
Blood tests
Bowel disease
Case reports
Chemotherapy
erytema nodosum
Family medical history
Leukemia
malignant homeopathy
Sarcoidosis
Skin diseases
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Summary:Introduction: Erythema nodosum (EN) is the most common type of panniculitis. It may be idiopathic or secondary to various etiologies. However, the occurrence of erythema nodosum in malignant hemopathy had rarely been reported. Case report: A 42 year-old woman presented with a four week history of recurrent multiple painful erythematous nodules developed on the lower limbs associated with arthralgia of the ankles and fever. The clinical features of skin lesions with contusiform color evolution allowed establishing the diagnosis of EN. No underlying cause was found. The skin lesions were improved with non-steroidal anti-inflammatory drugs and colchicine. Three months later, the patient consulted for recurrence of EN associated with fever, inflammatory polyarthralgia and hepatosplenomegaly. The peripheral blood count revealed pancytopenia. A bone marrow examination confirmed the diagnosis of acute myeloid leukemia type 2. Initiation of chemotherapy was followed by the complete disappearance of skin lesions of EN. Conclusion: Paraneoplastic erythema nodosum is a rare entity. In the literature, a few cases of association with leukemia have been reported. Exploration for solid neoplasms or hemopathy in case of recurrent EN or resistance to conventional treatment should be systematic.
ISSN:2081-9390
2081-9390
DOI:10.7241/ourd.20133.82