Review of the Traditional Uses, Phytochemistry, and Pharmacological Activities of Rhoicissus Species (Vitaceae)

• Published in: Molecules (Basel, Switzerland) Switzerland), 2021-04, Vol.26 (8), p.2306
• Main Authors: Dube, Nondumiso P, Siwe-Noundou, Xavier, Krause, Rui W M, Kemboi, Douglas, Tembu, Vuyelwa Jacqueline, Manicum, Amanda-Lee
• Format: Article
• Language: English
• Subjects: Anti-inflammatory agents; Antidiabetics; Antiinfectives and antibacterials; Antioxidants; Bioactive compounds; botany; Cancer; Climbing; cuneifolia; Diabetes mellitus; Infertility; Inflammation; Mode of action; Morphology; Natural products; Pharmaceutical industry; Pharmacology; phytochemistry; Plant diseases; Plant species; Review; Rhoicissus; Sexually transmitted diseases; STD; Uterus; Vegetation; Vitaceae
• ISSN: 1420-3049; 1420-3049
• DOI: 10.3390/molecules26082306

Species within the genus (Vitaceae) are commonly used in South African traditional medicine. The current review discusses the occurrence, distribution, traditional uses, phytochemistry, and pharmacological properties of species covering the period 1981-2020. The data reported were systematically collected, read, and analysed from scientific electronic databases including Scopus, Scifinder, Pubmed, and Google Scholar. Reported evidence indicates that species in this genus are used for the treatment of gastrointestinal complaints, sexually transmitted infections (STIs), and infertility, as well as to tone the uterus during pregnancy and to facilitate delivery. Pharmacological studies have further shown that members of the genus display antidiabetic, uterotonic, ascaricidal, hepatoprotective, antioxidant, antimicrobial, anticancer, and anti-inflammatory properties. They are linked to the presence of bioactive compounds isolated from the genus. Hence, species can potentially be an alternative therapeutic strategy to treat diseases and develop safer and more potent drugs to combat diseases. Plant species of this genus have valuable medicinal benefits due to their significant pharmacological potential. However, scientific investigation and information of the therapeutic potential of remain limited as most of the species in the genus have not been fully exploited. Therefore, there is a need for further investigations to exploit the therapeutic potential of the genus . Future studies should evaluate the phytochemical, pharmacological, and toxicological activities, as well as the mode of action, of crude extracts and secondary compounds isolated from the species.