The Lamellar Cells of Vertebrate Meissner and Pacinian Corpuscles: Development, Characterization, and Functions

Sensory corpuscles, or cutaneous end-organ complexes, are complex structures localized at the periphery of Aβ-axon terminals from primary sensory neurons that primarily work as low-threshold mechanoreceptors. Structurally, they consist, in addition to the axons, of non-myelinating Schwann-like cells...

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Bibliographic Details
Published in:Frontiers in neuroscience 2022-03, Vol.16, p.790130-790130
Main Authors: Suazo, Iván, Vega, José A, García-Mesa, Yolanda, García-Piqueras, Jorge, García-Suárez, Olivia, Cobo, Teresa
Format: Article
Language:English
Subjects:
Action potential
Axons
Corpuscles
Embryogenesis
Extracellular matrix
Glial cells
Ion channels
lamellar cells
Mechanoreceptors
Mechanotransduction
Morphology
Neuroscience
Neurotransmission
Pacinian corpuscles
Presynapse
sensory corpuscles
Sensory neurons
Skin
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Summary:Sensory corpuscles, or cutaneous end-organ complexes, are complex structures localized at the periphery of Aβ-axon terminals from primary sensory neurons that primarily work as low-threshold mechanoreceptors. Structurally, they consist, in addition to the axons, of non-myelinating Schwann-like cells (terminal glial cells) and endoneurial- and perineurial-related cells. The terminal glial cells are the so-called lamellar cells in Meissner and Pacinian corpuscles. Lamellar cells are variably arranged in sensory corpuscles as a "coin stack" in the Meissner corpuscles or as an "onion bulb" in the Pacinian ones. Nevertheless, the origin and protein profile of the lamellar cells in both morphotypes of sensory corpuscles is quite similar, although it differs in the expression of mechano-gated ion channels as well as in the composition of the extracellular matrix between the cells. The lamellar cells have been regarded as supportive cells playing a passive role in the process of genesis of the action potential, i.e., the mechanotransduction process. However, they express ion channels related to the mechano-electric transduction and show a synapse-like mechanism that suggest neurotransmission at the genesis of the electrical action potential. This review updates the current knowledge about the embryonic origin, development modifications, spatial arrangement, ultrastructural characteristics, and protein profile of the lamellar cells of cutaneous end-organ complexes focusing on Meissner and Pacinian morphotypes.
ISSN:1662-4548
1662-453X
1662-453X
DOI:10.3389/fnins.2022.790130