Fecal microbiota transplantation for ulcerative colitis: a prospective clinical study

• Published in: BMC gastroenterology 2019-07, Vol.19 (1), p.116-116, Article 116
• Main Authors: Tian, Yan, Zhou, Yan, Huang, Sisi, Li, Jun, Zhao, Kui, Li, Xiaohui, Wen, Xiangchen, Li, Xiao-An
• Format: Article
• Language: English
• Subjects: Aged; Care and treatment; Colitis, Ulcerative - therapy; Fecal microbiota transplantation; Fecal Microbiota Transplantation - methods; Female; Gastrointestinal Microbiome; Health aspects; Humans; Intestinal flora; Intestinal microorganisms; Male; Microbiota (Symbiotic organisms); Middle Aged; Prospective Studies; Remission Induction - methods; Treatment Outcome; Ulcerative colitis
• ISSN: 1471-230X; 1471-230X
• DOI: 10.1186/s12876-019-1010-4

Fecal microbiota transplantation may contribute to disease remission in ulcerative colitis; however, the factors that determine the effects of treatment remain unknown. The aim of the present study was to prospectively investigate the clinical efficacy of fecal microbiota transplantation in patients with ulcerative colitis and identify the bacterial signatures associated with clinical remission. A total of 20 patients with ulcerative colitis were included in this prospective and uncontrolled study. All patients underwent gastroscopy five times, once every 3 weeks. Clinical indices were used to assess the efficacy of fecal microbiota transplantation, as well as the Mayo score, a score used to evaluate the extent of intestinal mucosal lesions in patients with ulcerative colitis. The changes in intestinal flora were detected by 16S ribosomal RNA-sequencing, and the relationship between ulcerative colitis and intestinal flora was analyzed. After treatment, clinical index scores for diarrhea, abdominal pain, and blood stool decreased significantly (p