Soluble IL-2 Receptor in Dermatomyositis: Its Associations with Skin Ulcers and Disease Activity

Objective. To investigate the role of soluble interleukin-2R (sIL-2R) in idiopathic inflammatory myopathies (IIM). Methods. Serum sIL-2R levels were measured in 74 dermatomyositis (DM), 16 immune-mediated necrotizing myopathy (IMNM), 24 rheumatoid arthritis (RA), 20 systemic lupus erythematosus (SLE...

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Bibliographic Details
Published in:Mediators of inflammation 2020, Vol.2020 (2020), p.1-8
Main Authors: Wang, Guochun, Li, Sizhao, Ge, Yongpeng, Liu, Xia, Shu, Xiaoming, He, Linrong, Lu, Xin
Format: Article
Language:English
Subjects:
Adult
Age
Arthritis, Rheumatoid - blood
Autoimmune diseases
Autoimmune Diseases - blood
Biomarkers - blood
Blood tests
Clinical medicine
Comparative analysis
Dermatomyositis
Dermatomyositis - blood
Dermatomyositis - pathology
Disease
Electronic medical records
Ferritin
Humans
Inflammation
Inflammatory diseases
Interleukin 2
Interleukin 2 receptors
Interleukins
Laboratories
Lymphocytes
Lymphocytes T
Male
Medical prognosis
Middle Aged
Musculoskeletal diseases
Myopathy
Myositis
Pathogenesis
Patients
Receptors, Interleukin-2 - blood
Rheumatoid arthritis
Rheumatoid factor
Skin
Skin diseases
Skin lesions
Skin Ulcer - blood
Skin Ulcer - pathology
Somatotropin
Studies
Systemic lupus erythematosus
T cells
Ulcers
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Summary:Objective. To investigate the role of soluble interleukin-2R (sIL-2R) in idiopathic inflammatory myopathies (IIM). Methods. Serum sIL-2R levels were measured in 74 dermatomyositis (DM), 16 immune-mediated necrotizing myopathy (IMNM), 24 rheumatoid arthritis (RA), 20 systemic lupus erythematosus (SLE), and 20 healthy controls (HCs) by chemiluminescent immunometric assay. Clinical features and laboratory data were collected from electronic medical record. Disease activity was evaluated by using physician global disease activity and myositis disease activity assessment visual analog scale (MYOACT) on admission. 20 DM patients were followed. Serum sIL-2R levels were analyzed and compared with clinical features, laboratory data, and measures of disease activity. Results. Serum sIL-2R levels were significantly higher in DM patients than in IMNM patients and HCs (648.8±433.1 U/ml vs. 352.3±126.0 U/ml and 648.8±433.1 U/ml vs. 285.8±101.9 U/ml, respectively; all P
ISSN:0962-9351
1466-1861
DOI:10.1155/2020/6243019