Translational research in Chagas disease: perspectives in nutritional therapy emerging from selenium supplementation studies as a complementary treatment

Translational research (TR) is an interdisciplinary branch of the biomedical field that seeks to connect its three supporting pillars: basic research on the bench, the hospital beds and other health system services, and the delivery of products for the well-being and health of the community. Here, w...

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Bibliographic Details
Published in:Memórias do Instituto Oswaldo Cruz 2022-01, Vol.117, p.e220001-e220001
Main Authors: Araujo-Jorge, Tania C de, Ferreira, Roberto R
Format: Article
Language:English
Subjects:
Animals
Chagas Disease - drug therapy
Dietary Supplements
Humans
myocardiopathy
neglected tropical diseases
PARASITOLOGY
Retrospective Studies
selenium
Selenium - therapeutic use
trace elements
Translational Research, Biomedical
TROPICAL MEDICINE
Trypanosoma cruzi
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Summary:Translational research (TR) is an interdisciplinary branch of the biomedical field that seeks to connect its three supporting pillars: basic research on the bench, the hospital beds and other health system services, and the delivery of products for the well-being and health of the community. Here, we review the five transition stages of the TR spectrum, registering the lessons learned during > 20 years leading to the first clinical trial designed and performed in Brazil for testing a complementary treatment for Chagas disease (CD): the selenium trial (STCC). Lessons learned were: (1) to consider all the TR spectrum since the beginning of the project; (2) to start simultaneously animal studies and translation to humans; (3) to ensure a harmonious interaction between clinical and basic research teams; (4) to include MSc and PhD students only in pre-clinical and basic studies (TR0) or vertical clinical studies using retrospective samples and data (TR1); (5) to identify potential suppliers in the national commercial market for a future final treatment since the pre-clinical stage; (6) to keep an international network of experts as permanent advisers on the project. In the whole process, some perspectives were created: a complementary clinical trial for the opened questions and the construction of a Brazilian clinical CD platform.
ISSN:0074-0276
1678-8060
1678-8060
DOI:10.1590/0074-02760220001