The role of klotho in systemic sclerosis

The aim was to evaluate the role of klotho in the pathogenesis of systemic sclerosis (SSc), through the measurement of its serum concentration in SSc patients compared to healthy controls, and to assess the association with cutaneous and visceral involvement. Blood samples obtained from both SSc pat...

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Bibliographic Details
Published in:Reumatismo 2017-12, Vol.69 (4), p.156-163
Main Authors: Talotta, R, Bongiovanni, S, Letizia, T, Rigamonti, F, Atzeni, F, Benucci, M, Vago, T, Sarzi-Puttini, P
Format: Article
Language:English
Subjects:
Adult
Aged
Biomarkers
Female
Glucuronidase - blood
Glucuronidase - physiology
Humans
Immunosuppressive Agents - therapeutic use
klotho
Laboratories
Lung - pathology
Male
Microscopic Angioscopy
Middle Aged
Osteoporosis - etiology
Prostaglandins - therapeutic use
Scleroderma
Scleroderma, Systemic - blood
Scleroderma, Systemic - complications
Scleroderma, Systemic - drug therapy
Scleroderma, Systemic - pathology
Statistics, Nonparametric
Systemic sclerosis
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Summary:The aim was to evaluate the role of klotho in the pathogenesis of systemic sclerosis (SSc), through the measurement of its serum concentration in SSc patients compared to healthy controls, and to assess the association with cutaneous and visceral involvement. Blood samples obtained from both SSc patients and healthy controls were analysed by an ELISA assay for the detection of human klotho. SSc patients were globally evaluated for disease activity and assessed through the modified Rodnan's Skin Score, Medsger's scale, pulmonary function tests, 2D-echocardiography, nailfold capillaroscopy and laboratory tests. Our cohort consisted of 69 SSc patients (61 females, mean age 64.5±12.5 years, median disease duration 9.0 (IQR 8) years) and 77 healthy controls (28 females, mean age 49.7±10.2 years). In the group of SSc patients, 19 (27.5%) suffered from a diffuse form of SSc. All patients were receiving IV prostanoids, and some of them were concomitantly treated with immunosuppressive drugs (prednisone, hydroxychloroquine, mofetil mycophenolate, methotrexate, cyclosporin A and azathioprine). The median serum concentration of klotho was significantly lower in patients compared to controls (0.23 ng/mL vs 0.60 ng/mL; p
ISSN:0048-7449
2240-2683
DOI:10.4081/reumatismo.2017.987