Thyrotropinoma and multinodular goiter: A diagnostic challenge for hyperthyroidism

Thyroid disorders are frequently encountered. The diagnosis is straightforward unless clinical or laboratory findings are inconclusive and/or perplexing. Hyperthyroidism due to a thyrotropin-secreting pituitary adenoma rarely occurs and symptoms due to thyroid hormone excess are subtle. The presenta...

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Bibliographic Details
Published in:Journal of research in medical sciences 2013-11, Vol.18 (11), p.1008-1010
Main Authors: Aksoy, Duygu Yazgan, Gedik, Arzu, Cinar, Nese, Soylemezoglu, Figen, Berker, Mustafa, Gurlek, Omer Alper
Format: Article
Language:English
Subjects:
Case Report
Central hyperthyroidism
thyrotropinoma (TSHoma)
toxic goiter
toxic nodular goiter
TSH-secreting adenoma
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Summary:Thyroid disorders are frequently encountered. The diagnosis is straightforward unless clinical or laboratory findings are inconclusive and/or perplexing. Hyperthyroidism due to a thyrotropin-secreting pituitary adenoma rarely occurs and symptoms due to thyroid hormone excess are subtle. The presentation of the disease becomes unusual when co-secretion of other hormones with thyrotropin or concomitant thyroid parenchymal pathology exist. We present the case of a 63-year-old female patient with thyrotropinoma co-secreting growth hormone and multinodular goiter. She developed hyperthyroidism first due to thyrotropinoma and later due to a toxic nodule. Herein, we discuss the diagnostic and therapeutic challenges of hyperthyroidism with atypical presentation.
ISSN:1735-1995
1735-7136