Pd0-Catalyzed Methyl Transfer on Nucleosides and Oligonucleotides, Envisaged as a PET Tracer

The methyl transfer reaction from activated monomethyltin, via a modified Stille coupling reaction, was studied under “ligandless” conditions on fully deprotected 5'-modified nucleosides and one dinucleotide. The reaction was optimized to proceed in a few minutes and quantitative yield, even un...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2013-11, Vol.18 (11), p.13654-13665
Main Authors: James, Damien, Escudier, Jean-Marc, Szlosek-Pinaud, Magali, Fouquet, Eric
Format: Article
Language:English
Subjects:
Carbon
Ligands
methyl transfer
nucleosides
oligonucleotides
Palladium
Positron Emission Tomography
Stille coupling
Tomography
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Summary:The methyl transfer reaction from activated monomethyltin, via a modified Stille coupling reaction, was studied under “ligandless” conditions on fully deprotected 5'-modified nucleosides and one dinucleotide. The reaction was optimized to proceed in a few minutes and quantitative yield, even under dilute conditions, thus affording a rapid and efficient new method for oligonucleotide labelling with carbon-11.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules181113654