Novel Horizons in Postbiotics: Lactobacillaceae Extracellular Vesicles and Their Applications in Health and Disease

probiotics contained in dietary supplements or functional foods are well-known for their beneficial properties exerted on host health and diverse pathological situations. Their capacity to improve inflammatory bowel disease (IBD) and regulate the immune system is especially remarkable. Although bact...

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Bibliographic Details
Published in:Nutrients 2022-12, Vol.14 (24), p.5296
Main Authors: González-Lozano, Elena, García-García, Jorge, Gálvez, Julio, Hidalgo-García, Laura, Rodríguez-Nogales, Alba, Rodríguez-Cabezas, María Elena, Sánchez, Manuel
Format: Article
Language:English
Subjects:
Acne
Bacteria
By products
Carbohydrates
Carbon
Disease
EVs
Extracellular vesicles
Extracellular Vesicles - metabolism
Fatty acids
Functional foods & nutraceuticals
Gram-positive bacteria
Homeostasis
Humans
IBD
Immune System
Immunocompromised hosts
immunomodulation
inflammation
Inflammatory bowel diseases
Inflammatory Bowel Diseases - metabolism
Inflammatory Bowel Diseases - therapy
Lactobacillaceae
Lactobacillus
Lactobacillus - metabolism
Lipid bilayers
Lipids
Metabolism
Metabolites
Microbiota
Microorganisms
postbiotics
Probiotics
Review
Signal transduction
Skin
Vagina
Vesicles
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Summary:probiotics contained in dietary supplements or functional foods are well-known for their beneficial properties exerted on host health and diverse pathological situations. Their capacity to improve inflammatory bowel disease (IBD) and regulate the immune system is especially remarkable. Although bacteria-host interactions have been thought to occur directly, the key role that extracellular vesicles (EVs) derived from probiotics play on this point is being unveiled. EVs are lipid bilayer-enclosed particles that carry a wide range of cargo compounds and act in different signalling pathways. Notably, these EVs have been recently proposed as a safe alternative to the utilisation of live bacteria since they can avoid the possible risks that probiotics may entail in vulnerable cases such as immunocompromised patients. Therefore, this review aims to give an updated overview of the existing knowledge about EVs from different strains, their mechanisms and effects in host health and different pathological conditions. All of the information collected suggests that EVs could be considered as potential tools for the development of future novel therapeutic approaches.
ISSN:2072-6643
2072-6643
DOI:10.3390/nu14245296