Electrocardiographic Findings in Mexican Chagasic Subjects Living in High and Low Endemic Regions of Trypanosoma cruzi Infection

In México the first human chronic chagasic case was recognized in 1940. In spite of an increasing number of cases detected since that time, Chagas disease in México has been poorly documented. In the present work we studied 617 volunteers subjects living in high and low endemic regions of Trypanosom...

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Bibliographic Details
Published in:Memórias do Instituto Oswaldo Cruz 2003-07, Vol.98 (5), p.605-610
Main Authors: Sosa-Jurado, F, Mazariego-Aranda, M, Hernandez-Becerril, N, Garza-Murillo, V, Cardenas, M, Reyes, P A, Hirayama, K, Monteon, V M
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Animals
Chagas Cardiomyopathy - diagnosis
Chagas Cardiomyopathy - epidemiology
Chagas Cardiomyopathy - physiopathology
Chagas disease
Chagas disease - Trypanosoma cruzi - electrocardiogram alterations - seroprevalence - polymerase chain reaction
Child
electrocardiogram alterations
Electrocardiography
Endemic Diseases
Female
Humans
Male
Mexico - epidemiology
Middle Aged
PARASITOLOGY
polymerase chain reaction
Rural Population
Seroepidemiologic Studies
seroprevalence
TROPICAL MEDICINE
Trypanosoma cruzi
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Summary:In México the first human chronic chagasic case was recognized in 1940. In spite of an increasing number of cases detected since that time, Chagas disease in México has been poorly documented. In the present work we studied 617 volunteers subjects living in high and low endemic regions of Trypanosoma cruzi infection with seroprevalence of 22% and 4% respectively. Hemoculture performed in those seropositive subjects failed to demonstrate circulating parasites, however polymerase chain reaction identified up to 60% of them as positives. A higher level of anti-T. cruzi antibodies was observed in seropositive residents in high endemic region, in spite of similar parasite persistence (p < 0.05). On standard 12 leads electrocardiogram (ECG) 20% to 22% seropositive individuals from either region showed right bundle branch block or ventricular extrasystoles which were more prevalent in seropositive than in seronegative individuals (p < 0.05). In conclusion, the frequency or type of ECG abnormality was influenced by serologic status but not by endemicity or parasite persistence. Furthermore, Mexican indeterminate patients have a similar ECG pattern to those reported in South America.
ISSN:1678-8060
0074-0276
0074-0276
1678-8060
DOI:10.1590/S0074-02762003000500004