Interactions between Medical Plant-Derived Bioactive Compounds: Focus on Antimicrobial Combination Effects

It is accepted that the medicinal use of complex mixtures of plant-derived bioactive compounds is more effective than purified bioactive compounds due to beneficial combination interactions. However, synergy and antagonism are very difficult to study in a meticulous fashion since most established me...

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Bibliographic Details
Published in:Antibiotics (Basel) 2022-07, Vol.11 (8), p.1014
Main Authors: Vaou, Natalia, Stavropoulou, Elisavet, Voidarou, Chrysoula (Chrysa), Tsakris, Zacharias, Rozos, Georgios, Tsigalou, Christina, Bezirtzoglou, Eugenia
Format: Article
Language:English
Subjects:
Antagonism
Anti-infective agents
Antiinfectives and antibacterials
Antimicrobial activity
Antimicrobial agents
antimicrobial combination effects
Bioactive compounds
Bioavailability
Biological activity
Biological products
Chemical compounds
Complexity
Herbal medicine
Medicinal plants
Medicine, Botanic
Medicine, Herbal
Metabolism
Metabolites
Metabolomics
Mixtures
Plant extracts
Plants
Review
synergy
Systems science
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Summary:It is accepted that the medicinal use of complex mixtures of plant-derived bioactive compounds is more effective than purified bioactive compounds due to beneficial combination interactions. However, synergy and antagonism are very difficult to study in a meticulous fashion since most established methods were designed to reduce the complexity of mixtures and identify single bioactive compounds. This study represents a critical review of the current scientific literature on the combined effects of plant-derived extracts/bioactive compounds. A particular emphasis is provided on the identification of antimicrobial synergistic or antagonistic combinations using recent metabolomics methods and elucidation of approaches identifying potential mechanisms that underlie their interactions. Proven examples of synergistic/antagonistic antimicrobial activity of bioactive compounds are also discussed. The focus is also put on the current challenges, difficulties, and problems that need to be overcome and future perspectives surrounding combination effects. The utilization of bioactive compounds from medicinal plant extracts as appropriate antimicrobials is important and needs to be facilitated by means of new metabolomics technologies to discover the most effective combinations among them. Understanding the nature of the interactions between medicinal plant-derived bioactive compounds will result in the development of new combination antimicrobial therapies.
ISSN:2079-6382
2079-6382
DOI:10.3390/antibiotics11081014