Association of TP53 Single Nucleotide Polymorphisms with Prostate Cancer in a Racially Diverse Cohort of Men

Growing evidence indicates the involvement of a genetic component in prostate cancer (CaP) susceptibility and clinical severity. Studies have reported the role of germline mutations and single nucleotide polymorphisms (SNPs) of as possible risk factors for cancer development. In this single institut...

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Bibliographic Details
Published in:Biomedicines 2023-05, Vol.11 (5), p.1404
Main Authors: Duncan, Allison, Nousome, Darryl, Ricks, Randy, Kuo, Huai-Ching, Ravindranath, Lakshmi, Dobi, Albert, Cullen, Jennifer, Srivastava, Shiv, Chesnut, Gregory T, Petrovics, Gyorgy, Kohaar, Indu
Format: Article
Language:English
Subjects:
Alleles
Arg72Pro
Biopsy
Cell cycle
Gene frequency
Genetic testing
Genomes
Genotyping
Metastasis
Mortality
Mutation
p53 Protein
Pathology
Patients
Pro47Ser
Prostate cancer
Risk factors
Single-nucleotide polymorphism
SNP
Statistical analysis
Survival analysis
TP53
Tumors
White people
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Summary:Growing evidence indicates the involvement of a genetic component in prostate cancer (CaP) susceptibility and clinical severity. Studies have reported the role of germline mutations and single nucleotide polymorphisms (SNPs) of as possible risk factors for cancer development. In this single institutional retrospective study, we identified common SNPs in the gene in AA and CA men and performed association analyses for functional SNPs with the clinico-pathological features of CaP. The SNP genotyping analysis of the final cohort of 308 men (212 AA; 95 CA) identified 74 SNPs in the region, with a minor allele frequency (MAF) of at least 1%. Two SNPs were non-synonymous in the exonic region of : rs1800371 (Pro47Ser) and rs1042522 (Arg72Pro). The Pro47Ser variant had an MAF of 0.01 in AA but was not detected in CA. Arg72Pro was the most common SNP, with an MAF of 0.50 (0.41 in AA; 0.68 in CA). Arg72Pro was associated with a shorter time to biochemical recurrence (BCR) ( = 0.046; HR = 1.52). The study demonstrated ancestral differences in the allele frequencies of the Arg72Pro and Pro47Ser SNPs, providing a valuable framework for evaluating CaP disparities among AA and CA men.
ISSN:2227-9059
2227-9059
DOI:10.3390/biomedicines11051404