Gut Microbiota and Antidiabetic Drugs: Perspectives of Personalized Treatment in Type 2 Diabetes Mellitus

Alterations in the composition and function of the gut microbiota have been reported in patients with type 2 diabetes mellitus (T2DM). Emerging studies show that prescribed antidiabetic drugs distort the gut microbiota signature associated with T2DM. Even more importantly, accumulated evidence provi...

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Bibliographic Details
Published in:Frontiers in cellular and infection microbiology 2022-05, Vol.12, p.853771-853771
Main Authors: Liu, Wenhui, Luo, Zhiying, Zhou, Jiecan, Sun, Bao
Format: Article
Language:English
Subjects:
antidiabetic drugs
Cellular and Infection Microbiology
efficacy and safety
gut microbiota
personalized therapeutic targets
type 2 diabetes mellitus
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Summary:Alterations in the composition and function of the gut microbiota have been reported in patients with type 2 diabetes mellitus (T2DM). Emerging studies show that prescribed antidiabetic drugs distort the gut microbiota signature associated with T2DM. Even more importantly, accumulated evidence provides support for the notion that gut microbiota, in turn, mediates the efficacy and safety of antidiabetic drugs. In this review, we highlight the current state-of-the-art knowledge on the crosstalk and interactions between gut microbiota and antidiabetic drugs, including metformin, α-glucosidase inhibitors, glucagon-like peptide-1 receptor agonists, dipeptidyl peptidase-4 inhibitors, sodium-glucose cotransporter 2 inhibitors, traditional Chinese medicines and other antidiabetic drugs, as well as address corresponding microbial-based therapeutics, aiming to provide novel preventative strategies and personalized therapeutic targets in T2DM.
ISSN:2235-2988
2235-2988
DOI:10.3389/fcimb.2022.853771