Adhesive hydrogels in osteoarthritis: from design to application

Osteoarthritis (OA) is the most common type of degenerative joint disease which affects 7% of the global population and more than 500 million people worldwide. One research frontier is the development of hydrogels for OA treatment, which operate either as functional scaffolds of tissue engineering o...

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Bibliographic Details
Published in:Military medical research 2023-01, Vol.10 (1), p.4-4, Article 4
Main Authors: Duan, Wang-Lin, Zhang, Li-Ning, Bohara, Raghvendra, Martin-Saldaña, Sergio, Yang, Fei, Zhao, Yi-Yang, Xie, Yong, Bu, Ya-Zhong, Pandit, Abhay
Format: Article
Language:English
Subjects:
Adhesive hydrogel
Adhesives - therapeutic use
Cartilage regeneration
Functional additives
Humans
Hydrogels - therapeutic use
Interdisciplinary therapy
Osteoarthritis (OA)
Osteoarthritis - therapy
Review
Tissue Engineering
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Summary:Osteoarthritis (OA) is the most common type of degenerative joint disease which affects 7% of the global population and more than 500 million people worldwide. One research frontier is the development of hydrogels for OA treatment, which operate either as functional scaffolds of tissue engineering or as delivery vehicles of functional additives. Both approaches address the big challenge: establishing stable integration of such delivery systems or implants. Adhesive hydrogels provide possible solutions to this challenge. However, few studies have described the current advances in using adhesive hydrogel for OA treatment. This review summarizes the commonly used hydrogels with their adhesion mechanisms and components. Additionally, recognizing that OA is a complex disease involving different biological mechanisms, the bioactive therapeutic strategies are also presented. By presenting the adhesive hydrogels in an interdisciplinary way, including both the fields of chemistry and biology, this review will attempt to provide a comprehensive insight for designing novel bioadhesive systems for OA therapy.
ISSN:2054-9369
2095-7467
2054-9369
DOI:10.1186/s40779-022-00439-3