Accelerated tibia fracture healing in traumatic brain injury in accordance with increased hematoma formation

Traumatic brain injury (TBI) has been known to accelerate bone healing. Many cells and molecules have been investigated but the exact mechanism is still unknown. The neuroinflammatory state of TBI has been reported recently. We aimed to investigate the effect of TBI on fracture healing in patients w...

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Published in:BMC musculoskeletal disorders 2022-12, Vol.23 (1), p.1110-1110, Article 1110
Main Authors: Shim, Dong Woo, Hong, Hyunjoo, Cho, Kwang-Chun, Kim, Se Hwa, Lee, Jin Woo, Sung, Seung-Yong
Format: Article
Language:English
Subjects:
Adult
Bony Callus
Brain
Brain Injuries, Traumatic - complications
Brain Injuries, Traumatic - diagnostic imaging
Callus formation
Case-Control Studies
Development and progression
Female
Fracture Healing
Fractures
Fractures, Open
Healing
Hematoma
Humans
Injuries
Leg
Male
Medical research
Medicine, Experimental
Middle Aged
Patient outcomes
Retrospective Studies
Tibia
Tibial Fractures - complications
Tibial Fractures - diagnostic imaging
Tibial Fractures - surgery
Traumatic brain injury
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Summary:Traumatic brain injury (TBI) has been known to accelerate bone healing. Many cells and molecules have been investigated but the exact mechanism is still unknown. The neuroinflammatory state of TBI has been reported recently. We aimed to investigate the effect of TBI on fracture healing in patients with tibia fractures and assess whether the factors associated with hematoma formation changed more significantly in the laboratory tests in the fractures accompanied with TBI. We retrospectively investigated patients who were surgically treated for tibia fractures and who showed secondary bone healing. Patients with and without TBI were divided for comparative analyses. Radiological parameters were time to callus formation and the largest callus ratio during follow-up. Preoperative levels of complete blood count and chemical battery on admission were measured in all patients. Subgroup division regarding age, gender, open fracture, concomitant fracture and severity of TBI were compared. We included 48 patients with a mean age of 44.9 (range, 17-78), of whom 35 patients (72.9%) were male. There were 12 patients with TBI (Group 1) and 36 patients without TBI (Group 2). Group 1 showed shorter time to callus formation (P 
ISSN:1471-2474
1471-2474
DOI:10.1186/s12891-022-06063-5