Post-marketing surveilance study of creatine-guanidinoacetic acid safety in healthy adults

• Published in: Frontiers in nutrition (Lausanne) 2024-07, Vol.11, p.1414308
• Main Authors: Ranisavljev, Marijana, Todorovic, Nikola, Stajer, Valdemar, Ostojic, Sergej M
• Format: Article
• Language: English
• Subjects: adverse events; creatine; guanidinoacetic acid; homocysteine; Nutrition; safety
• ISSN: 2296-861X; 2296-861X
• DOI: 10.3389/fnut.2024.1414308

A post-marketing surveillance study assessed the adverse events and possible risk of elevated homocysteine levels after the supplementation with creatine-guanidinoacetic acid mixture in apparently healthy adults. The participants were recruited through social media platforms and online discussion boards, with side effects and total plasma homocysteine (T-Hcy) levels evaluated regularly during a supplementation period of 6 months. Thirthy eight individuals ( = 38, 34.2% female) completed the evaluation period and were included in the final analyses. Serious side effects were absent. Two participants (5.3%) reported transitional nausea during the introductory weeks of the supplementation; no participants stopped the treatment. Baseline T-Hcy levels were 11.6 ± 3.1 μmol/L (95% confidence interval [CI], from 10.6 to 12.6). The intervention induced a mild reduction in T-Hcy levels across the monitoring period (  = 0.028), with T-Hcy levels after 1, 2, 3, and 6 months were 10.4 ± 3.0 μmol/L, 10.6 ± 2.9 μmol/L, 10.1 ± 2.7 μmol/L, and 9.3 ± 2.8 μmol/L, respectively. These findings suggest the overall tolerability of creatine-guanidinoacetic mixture in healthy adults, with homocysteine-increasing risk of no concern.