Outcomes of patients with active cancer after transcatheter aortic valve replacement: an updated meta-analysis

• Published in: Cardio-oncology (London, England) England), 2024-09, Vol.10 (1), p.55-10, Article 55
• Main Authors: Felix, Nicole, Nogueira, Alleh, Carvalho, Pedro E P, Costa, Thomaz Alexandre, Tramujas, Lucas, Generoso, Giuliano, Feldman, Stephanie, Garot, Philippe, de Farias, Maria do Carmo Andrade Duarte
• Format: Article
• Language: English
• Subjects: Aortic stenosis; Aortic valve stenosis; Cancer; Cardio-oncology; Cardiovascular disease; Heart attacks; Life expectancy; Meta-analysis; Metastasis; Mortality; Neoplasms; Pacemakers; Patients; Statistical analysis; Transcatheter aortic valve replacement
• ISSN: 2057-3804; 2057-3804
• DOI: 10.1186/s40959-024-00256-8

Patients with active cancer and aortic stenosis may be under-referred for valve interventions due to concerns over a prohibitive risk. However, whether active cancer impacts outcomes after transcatheter aortic valve replacement (TAVR) remains unknown. We searched PubMed, Embase, and Cochrane Library in December 2023 for studies comparing the post-TAVR outcomes of patients with versus without active cancer. We pooled odds ratios (OR) and adjusted hazard ratios (aHR) with 95% confidence intervals (CI) applying a random-effects model. Statistical analyses were performed in R version 4.3.2. We included nine observational studies analyzing 133,906 patients, of whom 9,792 (7.3%) had active cancer. Compared with patients without cancer, patients with active cancer had higher short- (OR 1.33; 95% CI 1.15-1.55; p