Tween-20 transiently changes the surface morphology of PK-15 cells and improves PCV2 infection

Low concentrations of nonionic surfactants can change the physical properties of cell membranes, and thus and in turn increase drug permeability. Porcine circovirus 2 (PCV2) is an extremely slow-growing virus, and PCV2 infection of PK-15 cells yields very low viral titers. The present study investig...

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Bibliographic Details
Published in:BMC veterinary research 2018-04, Vol.14 (1), p.138-138, Article 138
Main Authors: Hua, Tao, Zhang, Xuehua, Tang, Bo, Chang, Chen, Liu, Guoyang, Feng, Lei, Yu, Yang, Zhang, Daohua, Hou, Jibo
Format: Article
Language:English
Subjects:
Cell membranes
Cellular morphologic change
DNA replication
Health aspects
Nonionic surfactant
PCV2
Swine
Tween-20
Viral infection
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Summary:Low concentrations of nonionic surfactants can change the physical properties of cell membranes, and thus and in turn increase drug permeability. Porcine circovirus 2 (PCV2) is an extremely slow-growing virus, and PCV2 infection of PK-15 cells yields very low viral titers. The present study investigates the effect of various nonionic surfactants, namely, Tween-20, Tween-28, Tween-40, Tween-80, Brij-30, Brij-35, NP-40, and Triton X-100 on PCV2 infection and yield in PK-15 cells. Significantly increased PCV2 infection was observed in cells treated with Tween-20 compared to those treated with Tween-28, Tween-40, Brij-30, Brij-35, NP-40, and Triton X-100 (p 
ISSN:1746-6148
1746-6148
DOI:10.1186/s12917-018-1457-5