Pediatric demographic association with hospital mortality in platelets- and plasma-transfused young pediatric patients — a mixed cohort study

• Published in: The Gazette of the Egyptian Paediatric Association 2024-12, Vol.72 (1), p.64-10, Article 64
• Main Authors: Sharma, Sankalp, Padhi, Phalguni
• Format: Article
• Language: English
• Subjects: Age groups; Apgar score; Blood platelets; Blood transfusion; Children; Cohort analysis; Comparative analysis; Confidence intervals; Demographic; Fresh; Frozen plasma; Gestational age; Health aspects; Hospital patients; Hospital stays; Hospitalization; Hypotheses; Laboratories; Length of stay; Length of stay before first transfusion; Medical prognosis; Medical research; Medicine; Medicine & Public Health; Medicine, Experimental; Mortality; Newborn babies; Patient outcomes; Patients; Pediatrics; Plasma; Premature babies; Premature birth; Prognosis; Thrombocytopenia; Variables
• ISSN: 2090-9942; 1110-6638; 2090-9942
• DOI: 10.1186/s43054-024-00302-1

Background Demographic and biochemical variations in newborn children as compared to adults are attributable to variable prognosis to blood transfusions. Aims of this mixed cohort study of Platelets with/without Plasma (PLT/PZ); only Plasma (PZ) transfusions in ≤ 24 months children is as follows: An Association of demography towards hospital mortality, and an association of laboratory investigations (LI) with hospital mortality. Methods PLT/PZ ( n  = 72) and PZ ( n  = 79) children ≤ 24 months were followed up for a total length of hospital stay (LOS(D)). We calculated the Odds Ratio (OR) of demographic, and laboratory parameters for mortality, survival studies of demographic, laboratory parameters , Kaplan Meier Survival curve, Log-Rank significance (KMLR) and Multivariable regression ( r 2 ) with outcome as death. Results The present study is in 2019–2022. Higher OR for hospital-based mortality for PLT/PZ and PZ cohort were age ≤ 1 m, weight ≤ 1500 g, preterm, gestational age ≤ 34 weeks, hospital length of stay {LOS(D)} 0–7 days, APGAR score ≤ 5, and Hb ≤ 7 g/dl. High OR, mortality was observed with Female gender, Length of stay before first transfusion {LOS(F)}, 0-7d, WHO Grade of bleeding (GOB) 4, PT >50 sec, INR >1·7, aPTT >75sec, PLT counts (μl) ≤25000/μl (PLT/PZ) and GOB 3, 4 (PZ). Higher OR for mortality was also observed with a lower derangement of coagulative parameters PT ≤50s, INR ≤1·7, aPTT ≤75s (PZ). Higher survival was observed for (PLT/PZ) LOS(F) 0–7 days across age (m), weight (g) ( P  = 0·002;