Matrix Metalloproteinase-9 Production following Cardiopulmonary Bypass Was Not Associated with Pulmonary Dysfunction after Cardiac Surgery

Background. Cardiopulmonary bypass (CPB) causes release of matrix metalloproteinase- (MMP-) 9, contributing to pulmonary infiltration and dysfunction. The aims were to investigate MMP-9 production and associated perioperative variables and oxygenation following CPB. Methods. Thirty patients undergoi...

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Bibliographic Details
Published in:Mediators of Inflammation 2015-01, Vol.2015 (2015), p.352-356-132
Main Authors: Tsai, Chien-Sung, Li, Chi-Yuan, Tsai, Yi-Ting, Wu, Zhi-Fu, Huang, Go-Shine, Hsu, Che-Hao, Lin, Yi-Wen, Lin, Feng-Yen, Lin, Tso-Chou, Lin, Chih-Yuan
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Anesthesiology
Cardiac Surgical Procedures - adverse effects
Cardiology
Cardiopulmonary bypass
Cardiopulmonary Bypass - adverse effects
Enzyme-Linked Immunosorbent Assay
Female
Heart
Heart surgery
Hospitals
Humans
Internal medicine
Intubation
Laboratories
Lung diseases
Male
Matrix Metalloproteinase 9 - metabolism
Medicine
Middle Aged
Patient outcomes
Physiological aspects
Pulmonary arteries
Respiratory distress syndrome
Rodents
Surgery
Time Factors
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Summary:Background. Cardiopulmonary bypass (CPB) causes release of matrix metalloproteinase- (MMP-) 9, contributing to pulmonary infiltration and dysfunction. The aims were to investigate MMP-9 production and associated perioperative variables and oxygenation following CPB. Methods. Thirty patients undergoing elective cardiac surgery were included. Arterial blood was sampled at 6 sequential points (before anesthesia induction, before CPB and at 2, 4, 6, and 24 h after beginning CPB) for plasma MMP-9 concentrations by ELISA. The perioperative laboratory data and variables, including bypass time, PaO2/FiO2, and extubation time, were also recorded. Results. The plasma MMP-9 concentrations significantly elevated at 2–6 h after beginning CPB (P
ISSN:0962-9351
1466-1861
DOI:10.1155/2015/341740