Emerging mechanisms progress of colorectal cancer liver metastasis

Colorectal cancer (CRC) is the third most common malignancy and the second most common cause of cancer-related mortality worldwide. A total of 20% of CRC patients present with distant metastasis. The hepatic portal venous system, responsible for collecting most intestinal blood, makes the liver the...

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Published in:Frontiers in endocrinology (Lausanne) 2022-12, Vol.13, p.1081585-1081585
Main Authors: Zhao, Wenhu, Dai, Shipeng, Yue, Lei, Xu, Fan, Gu, Jian, Dai, Xinzheng, Qian, Xiaofeng
Format: Article
Language:English
Subjects:
cancer stem cells
colorectal cancer
Colorectal Neoplasms - pathology
Colorectal Neoplasms - therapy
EMT
Endocrinology
Humans
liver metastasis
Liver Neoplasms
tumor micro environment
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container_title Frontiers in endocrinology (Lausanne)
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creator Zhao, Wenhu
Dai, Shipeng
Yue, Lei
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Gu, Jian
Dai, Xinzheng
Qian, Xiaofeng
description Colorectal cancer (CRC) is the third most common malignancy and the second most common cause of cancer-related mortality worldwide. A total of 20% of CRC patients present with distant metastasis. The hepatic portal venous system, responsible for collecting most intestinal blood, makes the liver the most common site of CRC metastasis. The formation of liver metastases from colorectal cancer is a long and complex process. It involves the maintenance of primary tumors, vasculature invasion, distant colonization, and metastasis formation. In this review, we serve on how the CRC cells acquire stemness, invade the vascular, and colonize the liver. In addition, we highlight how the resident cells of the liver and immune cells interact with CRC cells. We also discuss the current immunotherapy approaches and challenges we face, and finally, we look forward to finding new therapeutic targets based on novel sequencing technologies.
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subjects cancer stem cells
colorectal cancer
Colorectal Neoplasms - pathology
Colorectal Neoplasms - therapy
EMT
Endocrinology
Humans
liver metastasis
Liver Neoplasms
tumor micro environment
title Emerging mechanisms progress of colorectal cancer liver metastasis
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