Decreased Soluble Receptor of Advanced Glycation End Product Levels Correlated with Inflammation in Silicosis

• Published in: Mediators of inflammation 2020, Vol.2020 (2020), p.1-7
• Main Authors: Guo, Lingli, Hao, Xiaohui, Wang, Ying, Zhao, Xiaokun, Li, Enhong, Jiang, Tian, Ma, Jingjing, Liu, Heliang, Cui, Jie
• Format: Article
• Language: English
• Subjects: Adult; Advanced glycosylation end products; Biomarkers; Body mass index; Bone morphogenetic proteins; Cytokines; Cytokines - blood; Disease; Female; Glycosylation; Humans; IL-1β; Inflammation; Inflammation - blood; Inflammation - etiology; Inflammatory diseases; Inhalation; Interleukin 6; Interleukins; Lipoproteins, LDL - blood; Low density lipoprotein; Low density lipoproteins; Male; Middle Aged; Occupational exposure; Receptor for Advanced Glycation End Products - blood; Respiratory function; Silica; Silica dust; Silicosis; Silicosis - blood; Silicosis - etiology; Transforming growth factor-b1; Transforming growth factors; Tumor necrosis factor; Tumor necrosis factor-TNF; Tumor necrosis factor-α
• ISSN: 0962-9351; 1466-1861
• DOI: 10.1155/2020/2683753

Silicosis is a devastating disease caused by inhalation of silica dust that leads to inflammatory cascade and then scarring of the lung tissue. Increasing evidences indicate that soluble receptor for advanced glycation end products (sRAGE) is involved in inflammatory diseases. However, no data on the possible relationship between sRAGE and inflammation of silicosis are available. In this study, serum from subjects with silicosis (n=59) or from healthy controls (HC, n=14) was analyzed for the secretion of sRAGE, tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), interleukin-6 (IL-6), transforming growth factor-β1 (TGF-β1), and oxidized low-density lipoprotein (ox-LDL). The associations between sRAGE and cytokines and ox-LDL and lung function were assessed by Pearson’s correlation analyses. Mean levels of serum sRAGE were lower in silicosis than those in controls (p