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Could SCUBE-1 be a marker for subclinical atherosclerosis other than carotid artery intima-media thickness in patients with psoriasis?

Psoriasis is a chronic inflammatory disease that is associated with many inflammatory conditions such as atherosclerosis, hypertension, among others. SCUBE-1 is a protein that plays a role in angiogenesis. The present study aimed to investigate whether SCUBE-1 could indicate subclinical atherosclero...

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Published in:Anais brasileiros de dermatología 2023-09, Vol.98 (5), p.595-601
Main Authors: Ayvaz Çelik, Havva Hilal, Kuyumcu, Mevlüt Serdar, Şirin, Fevziye Burcu, Cirit, Mehmet, Korkmaz, Selma, Erturan, İjlal, Çelik, Seda, Yıldırım, Mehmet
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Language:English
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Summary:Psoriasis is a chronic inflammatory disease that is associated with many inflammatory conditions such as atherosclerosis, hypertension, among others. SCUBE-1 is a protein that plays a role in angiogenesis. The present study aimed to investigate whether SCUBE-1 could indicate subclinical atherosclerosis in psoriatic patients, and to compare SCUBE-1 levels, measurement of carotid artery ıntima-media thickness (CIMT), and metabolic parameters in psoriasis patients and healthy controls. Forty-six patients with psoriasis and 43 healthy controls were included. The severity of the disease was assessed with Psoriasis Area Severity Index (PASI) in the patient group. Levels of SCUBE-1, CRP, lipids, and fasting glucose were measured with the enzyme-linked ımmunosorbent assay (ELISA) method, and CIMT measurements were performed by the same cardiologist. SCUBE-1 levels and CIMT values were significantly higher in the patient group (for both p 
ISSN:0365-0596
1806-4841
1806-4841
DOI:10.1016/j.abd.2022.08.012